Altered Sca-1+ Progenitor Cell Populations in Diabetic Mice Are Associated with Increased Neointimal Hyperplasia After Vascular Injury

Diabetic patients exhibit poor outcomes after vascular interventions, predominantly due to development of neointimal hyperplasia. While diabetic mice have been shown to have diminished Sca-1+ stem cells in their bone marrow, the role of Sca-1+ cells in the vasculature is unknown. We hypothesize that diabetic mice have diminished Sca-1+ stem cell populations in the arterial wall compared with wild type (WT) mice. We also hypothesize that vascular injury will alter the presence and distribution of Sca-1+ cells in the arterial wall.

Source: Journal of Vascular Surgery - October 28, 2013 Category: Surgery Authors: Jill R. Streams, Janet Martinez, Megan Flynn, Melina R. Kibbe Tags: Abstracts from the 2013 Midwestern Vascular Surgical Society Annual Meeting Source Type: research