Biomarkers, oxidative stress and autophagy in skin aging.
Biomarkers, oxidative stress and autophagy in skin aging. Ageing Res Rev. 2020 Feb 24;:101036 Authors: Gu Y, Han J, Jiang C, Zhang Y Abstract Aging is a major cause of many degenerative diseases. The most intuitive consequence of aging is mainly manifested on the skin, resulting in cumulative changes in skin structure, function and appearance, such as increased wrinkles, laxity, elastosis, telangiectasia, and aberrant pigmentation of the skin. Unlike other organs of the human body, skin is not only inevitably affected by the intrinsic aging process, but also affected by various extrinsic environmental factors to accelerate aging, especially ultraviolet (UV) radiation. Skin aging is a highly complex and not fully understood process, and the lack of universal biomarkers for the definitive detection and evaluation of aging is also a major research challenge. Oxidative stress induced by the accumulation of reactive oxygen species (ROS) can lead to lipid, protein, nucleic acid and organelle damage, thus leading to the occurrence of cellular senescence, which is one of the core mechanisms mediating skin aging. Autophagy can maintain cellular homeostasis when faced with different stress conditions and is one of the survival mechanisms of cell resistance to intrinsic and extrinsic stress. Autophagy and aging have many features in common and may be associated with skin aging mediated by different factors. Here, we summarize the changes and biomarkers of skin agin...
Authors: Messaadi N, Bayen S, Beghin L, Lefebvre JM, Colleau S, Deken V, Cottencin O, Quersin F, Descamps A, Vanhelst J Abstract BACKGROUND: Screen media usage has become increasingly commonplace in daily life with children initiating themselves to screen media at an early age. Given the high prevalence of screen viewing among children worldwide, its impact on children's health has become a cause for concern. Unfortunately, little information on the independent association between sleep habits and screen time in French children is currently available. The main aim of this study was to assess possible...
Publication date: Available online 28 May 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of LipidsAuthor(s): Aline Bayerle, Christian Marsching, Mariona Rabionet, Shaalee Dworski, Mustafa A. Kamani, Chandramohan Chitraju, Nina L. Gluchowski, Katlyn R. Gabriel, Silke Herzer, Richard Jennemann, Thierry Levade, Jeffrey A. Medin, Roger Sandhoff
PMID: 32464083 [PubMed - as supplied by publisher]
Conclusions: EVs from buffaloes infected with Theileria spp. were successfully isolated and characterized. This is an advance in the knowledge of host-parasite relationship that contributes to the understanding of host immune response and theileriosis evasion mechanisms. These findings may pave the way for searching new EVs candidate-markers for a better production of safe biological products derived from buffaloes.
Conclusions: JZTX-X selectively suppresses Kv4.2 and Kv4.3 potassium channe l activity in a concentration- and voltage-dependent manner and causes long-lasting mechanical hyperalgesia.
Conclusion: Our results suggest a different biochemical composition of S. polymorpha venom, based on the different effects of four venom fractions on the cells tested, according to statistical evidence. Fractions F6 and F7 caused the most important alterations.
Publication date: Available online 29 May 2020Source: The Annals of Thoracic SurgeryAuthor(s): Irsa S. Hasan, Hartzell V. Schaff, Richard C. Daly, Katherine S. King, John M. Stulak, Kevin L. Greason, Joseph A. Dearani
Publication date: Available online 29 May 2020Source: The Annals of Thoracic SurgeryAuthor(s): Takafumi Ouchi, Noriyuki Kato, Hiroaki Kato, Takatoshi Higashigawa, Hisato Ito, Ken Nakajima, Shuji Chino, Toshiya Tokui, Toru Mizumoto, Hajime Sakuma
Publication date: September 2020Source: Interdisciplinary Neurosurgery, Volume 21Author(s): Nobuya Murakami, Takato Morioka, Satoshi O. Suzuki, Nobutaka Mukae, Takafumi Shimogawa, Yoshihiro Matsuo, Takakazu Sasaguri, Masahiro Mizoguchi
Publication date: September 2020Source: Interdisciplinary Neurosurgery, Volume 21Author(s): Zachary K. Christian, Kimmo J. Hatanpaa, Richard J. Auchus, Stephen R. Hammes, Ankur R. Patel, Bruce E. Mickey