Local Irradiation Modulates the Pharmacokinetics of Metabolites in 5-Fluorouracil —Radiotherapy–Pharmacokinetics Phenomenon

ConclusionBoth conventional and low-dose irradiation can affect the pharmacokinetics of 5-FU and its metabolite, 5-FDHU. RT plus 5-FU could cause more adverse events than 5-FU alone by increasing the AUC ratio of 5-FU/5-FDHU. Irradiation decreases the AUC of 5-FU in the plasma, which may cause poor clinical outcomes.
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research