Socioeconomic status and disease-modifying therapy prescribing patterns in people with multiple sclerosis

Publication date: Available online 24 February 2020Source: Multiple Sclerosis and Related DisordersAuthor(s): Saúl Reyes, Sebastian Suarez, Kimberley Allen-Philbey, Özlem Yildiz, Joela Mathews, Grace Anjorin, Freya Edwards, Cherry Jain, Benjamin Turner, Monica Marta, Sharmilee Gnanapavan, Klaus Schmierer, Gavin Giovannoni
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research

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Authors: de Seze J, Bigaut K Abstract During the 20 past years, the management of multiple sclerosis (MS) has largely changed especially concerning therapeutical approach. Before 1996, treatments were restricted to corticosteroids for relapses, several symptomatic treatments and unselective immunosuppressive drugs (azathioprine, cyclophosphamide, methotrexate) with a low evidence of any efficacy. In the present review, we analyze the principal real-life cohorts of MS during several periods (before therapeutical modern area, first-generation treatment area and most recent period). Despite many methodological problem...
Source: Revue Neurologique - Category: Neurology Tags: Rev Neurol (Paris) Source Type: research
Authors: Kremer S PMID: 32265071 [PubMed - as supplied by publisher]
Source: Revue Neurologique - Category: Neurology Tags: Rev Neurol (Paris) Source Type: research
Publication date: Available online 8 April 2020Source: Multiple Sclerosis and Related DisordersAuthor(s): David Kremer, Vivien Weyers, Joel Gruchot, Peter Göttle, Hans-Peter Hartung, Hervé Perron, Patrick Küry
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Conclusion: ART may reduce the risk of NCIs in HIV-infected patients in general. Further research to investigate NCIs on specific antiretroviral regimens and comorbidities may provide insights regarding the long-term clinical care of these patients.
Source: AIDS - Category: Infectious Diseases Tags: EPIDEMIOLOGY AND SOCIAL Source Type: research
I have a patient with multiple sclerosis who is taking ocrelizumab infusions who has external resorption on the distal of her upper right first premolar. I have declined to offer implant treatment for fear of possible medication induced osteonecrosis of the jaw. I would views.The postOcrelizumab: External Resorption and Implant Treatment? appeared first onOsseoNews Dental Implants.
Source: Dental Implants Discussed by Experts - Category: Dentistry Authors: Tags: Clinical Cases Surgical Source Type: news
Contributors : Andrew S Mendiola ; Katerina AkassoglouSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusOxidative stress is a central part of innate-immune induced neurodegeneration. However, the transcriptomic landscape of the central nervous system (CNS) innate immune cells contributing to oxidative stress is unknown, and therapies to target their neurotoxic functions are not widely available. Here, we provide the oxidative stress innate immune cell atlas in neuroinflammatory disease, and report the discovery of new druggable pathways. Transcriptional profiling of oxidative stress-pro...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Contributors : Andrew S Mendiola ; Katerina AkassoglouSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusOxidative stress is a central part of innate-immune induced neurodegeneration. However, the transcriptomic landscape of the central nervous system (CNS) innate immune cells contributing to oxidative stress is unknown, and therapies to target their neurotoxic functions are not widely available. Here, we provide the oxidative stress innate immune cell atlas in neuroinflammatory disease, and report the discovery of new druggable pathways. Transcriptional profiling of oxidative stress-pro...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Publication date: Available online 8 April 2020Source: NeuroImageAuthor(s): Dinesh K. Sivakolundu, Kathryn L. West, Mark Zuppichini, Monroe P. Turner, Dema Abdelkarim, Yuguang Zhao, Jeffrey S. Spence, Hanzhang Lu, Darin T. Okuda, Bart Rypma
Source: NeuroImage - Category: Neuroscience Source Type: research
by The PLOS Genetics Editors
Source: PLoS Genetics - Category: Genetics & Stem Cells Authors: Source Type: research
Natalizumab (NTZ) and autologous hematopoietic stem cell transplantation (AHSCT) are two successful treatments for relapsing-remitting multiple sclerosis (RRMS), an autoimmune T-cell-driven disorder affecting the central nervous system that is characterized by relapses interspersed with periods of complete or partial recovery. Both RRMS treatments have been documented to impact T-cell subpopulations and the T-cell receptor (TCR) repertoire in terms of clone frequency, but, so far, the link between T-cell naive and memory populations, autoimmunity, and treatment outcome has not yet been established hindering insight into th...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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