Novel Drug Benefits Bone and Cartilage in Knee Osteoarthritis

An investigational selective cathepsin K inhibitor called MIV-711 failed to decrease knee osteoarthritis pain but attenuated bone area progression and reduced cartilage volume loss, a multicenter European trial reported in the Annals of Internal Medicine.
Source: JAMA - Category: General Medicine Source Type: research

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Conclusion: The current review identified strong, high-quality evidence to recommend hip muscle strengthening in the conservative management of persons with knee OA. Further research is needed to establish the underlying mechanisms for the clinical benefits.
Source: Journal of Geriatric Physical Therapy - Category: Physiotherapy Tags: Systematic Reviews Source Type: research
Meniscal tears are commonly observed on MRIs obtained in middle-aged and older adults, with some studies suggesting a 35% prevalence in the 50-and-older population (1). Not all tears are symptomatic, but patients with these tears often seek treatment when they experience pain, swelling, or interference with valued activities. Physical therapy (PT) and arthroscopic partial meniscectomy (APM) are among the treatment options available to these patients, with clinical trials showing similar benefits in terms of pain and functional improvement for both (2).
Source: Osteoarthritis and Cartilage - Category: Rheumatology Authors: Tags: Editorial Source Type: research
Trapeziometacarpal (TMC) osteoarthritis can be painful and cause disability for patients. Total joint replacement of the TMC joint provides a pseudo arthrosis with good restoration of the thumb motion and pain...
Source: Health and Quality of Life Outcomes - Category: International Medicine & Public Health Authors: Tags: Research Source Type: research
This study compares psychological and somatosensory characteristics between those with persistent PFP and controls.Methods150 adults with PFP were compared to 61 controls. All participants completed a survey evaluating participant characteristics, PFP ‐related constructs and psychological factors: anxiety, depression, pain catastrophizing, kinesiophobia, pain self‐efficacy. Participants also attended a session of somatosensory testing, which included knee and elbow thermal and mechanical detection and pain thresholds, conditioned pain modulat ion (CPM), and temporal summation of pain (TSP). Differences were evaluated u...
Source: European Journal of Pain - Category: Anesthesiology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Conclusions: According to these characteristics, tapentadol appears suitable in the treatment of severe uncontrolled chronic pain characterized by both a nociceptive and a neuropathic component, such as osteoarthritis or back pain. PMID: 32216591 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
The aim of the study is to assess the safety and efficacy of Imhäuser osteotomy combined with osteochondroplasty in the treatment of moderate-severe stable slipped capital femoral epiphysis (SCFE) on short-term basis. Nineteen patients (20 hips) with moderate-severe stable SCFE were surgically treated by Imhäuser osteotomy combined with osteochondroplasty and followed up for 3–4 years. The cases aged between 12 and 18 years at the time of surgery and complained of a variety of symptoms and signs that included pain, limping, limited range of motion (ROM), and/or abductor weakness. The outcomes were assessed ...
Source: Journal of Pediatric Orthopaedics B - Category: Orthopaedics Tags: Pelvis & Hip Source Type: research
Conclusion: Muscle strength as measured by grip strength and knee extension was statistically significantly correlated with the WOMAC scores in patients with knee symptoms regardless of whether radiologic signs of knee osteoarthritis were observed.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Condition:   Knee Osteoarthritis Interventions:   Other: High Intensity LASER Therapy (HILT);   Other: Ibuprofen Gel Phonophoresis (IGP);   Other: Transcranial Direct Current Stimulation (tDCS);   Other: Conventional Physiotherapy (CPT) Sponsor:   Asir John Samuel Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Knee Osteoarthritis Interventions:   Other: Transcranial direct current stimulation;   Other: Conventional Physiotherapy Sponsors:   Maharishi Markendeswar University;   Maharishi Markandeshwar Medical College and Hospital, Kumarhatti, Solan;   Himachal Pradesh Council for Science Technology and Environment (HIMCOSTE) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Knee Osteoarthritis Interventions:   Other: High Intensity LASER Therapy (HILT);   Other: Ibuprofen Gel Phonophoresis (IGP);   Other: Transcranial Direct Current Stimulation (tDCS);   Other: Conventional Physiotherapy (CPT) Sponsors:   Asir John Samuel;   Maharishi Markendeswar University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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