A closed-loop brain–machine interface framework design for motor rehabilitation
Publication date: April 2020Source: Biomedical Signal Processing and Control, Volume 58Author(s): Hongguang Pan, Wenyu Mi, Xinyu Lei, Jun DengAbstractBrain–machine interfaces (BMIs) can be adopted to rehabilitate motor systems for disabled subjects by sensing cortical neuronal activities and creating new method. In this paper, to achieve the function of motor rehabilitation, two generalized BMI frameworks, including decoders, encoders and auxiliary controllers, are proposed and compared based on a classical single-joint information transmission model. Firstly, a decoder based on the Wiener filter and an encoder based on a network of spiking neurons are designed to compensate for the absent information pathway, and a charge-balanced intra-cortical microstimulation current is chosen as the input of the spiking neuron network; Secondly, to formulate closed-loop BMI frameworks, two auxiliary controllers are designed according to the strategy of model predictive control, where the controller inputs are the position of joint muscle trajectories and the average firing activity trajectories of perceived position vector neurons. Thirdly, considering that several integer parameters are included in the charge-balanced intra-cortical microstimulation current and that the optimization problem for solving the control inputs also includes these decision variables, a particle swarm optimization algorithm is adopted to solve the hard optimization problem. We compare the motor recovery e...
Publication date: June 2020Source: Research in Developmental Disabilities, Volume 101Author(s): Rabya Mughal, Anna Joyce, Catherine Hill, Dagmara Dimitriou
CONCLUSIONS: We report a fetus with Kabuki syndrome 2 detected using CMA. It is strongly recommended that CMA be included in prenatal diagnosis in fetuses with growth retardation, cardiovascular and musculoskeletal abnormalities revealed by routine Color Doppler ultrasonography. PMID: 32211113 [PubMed]
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Purpose of review Despite its critical roles in body movement, structure, and metabolism, skeletal muscle remains underappreciated in the context of rheumatoid arthritis. In rheumatoid arthritis, chronic inflammation, physical inactivity, and medication toxicities impair skeletal muscle. These skeletal muscle alterations contribute to continued rheumatoid arthritis disparities in physical function and cardiometabolic health. Recent findings In the prebiologic disease-modifying antirheumatic drug era, rheumatoid arthritis skeletal muscle atrophy was the central feature of ‘rheumatoid cachexia,’ a hypermetab...
Conclusions: Pediatric physical therapists play a critical role in working with families to promote their self-efficacy for using the modified ride-on car and their capacity for overcoming the inherent difficulties associated with use. Most of the reported perceived barriers are modifiable, at least to some degree, with likely effects on modified ride-on car use.
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Conclusions: Our model predicts the gap between estimates of ideally and actually embedding school-based physical therapy services. While 4 variables predicted the gap, further research is needed to develop a predictive model of actual practice to inform school-based physical therapy practice.
Brexpiprazole is a new atypical antipsychotic for schizophrenia management and as adjunct in major depressive disorder (MDD). We searched randomized controlled trials (RCT) to review brexpiprazole efficacy and tolerability in acute management of schizophrenia and MDD using PubMed, EUDRACT, ClinicalTrials.gov and Cochrane Central Register of Controlled Trials. A meta-analysis was conducted using the identified 14 RCT to assess its efficacy using positive and negative syndrome scale (PANSS), clinical global impressions – severity of illness (CGI-S), personal and social performance scale (PSP), Montgomery–Ås...
ConclusionsPsychosocial interventions should address problems of anxiety and depression that people with MDs frequently experience, even through fostering parents ’ and childrens’ engagement coping over disengagement coping.
ConclusionIn Ethiopia, a low percentage of individuals with SMIs initiate psychiatric treatment and many discontinue this to attend spiritual healing. In this study, the Ethiopian SMI patients engaged consistently in psychiatric treatment indicated high mean subjective recovery scores. Devising mechanisms to integrate the psychiatric treatment and spiritual healing sectors are suggested. Approaches to improve quality of life, functioning, hope, internalized stigma and provide need-based social support are suggested.