N-acetylcysteine for the treatment of comorbid alcohol use disorder and posttraumatic stress disorder: Design and methodology of a randomized clinical trial

Alcohol use disorder (AUD) and posttraumatic stress disorder (PTSD) are two prevalent psychiatric conditions in the U.S. The co-occurrence of AUD and PTSD is also common, and associated with a more severe clinical presentation and worse treatment outcomes across the biopsychosocial spectrum (e.g., social and vocational functioning, physical health) as compared to either disorder alone. Despite the high co-occurrence and negative outcomes, research on effective medications for AUD/PTSD is sparse and there is little empirical evidence to guide treatment decisions.

Source: Contemporary Clinical Trials - February 18, 2020 Category: Radiology Authors: Sudie E. Back, Kevin Gray, Elizabeth Santa Ana, Jennifer L. Jones, Amber M. Jarnecke, Jane E. Joseph, James Prisciandaro, Therese Killeen, Delisa G. Brown, Linda Taimina, Ebele Compean, Robert Malcolm, Julianne C. Flanagan, Peter W. Kalivas Source Type: research