Outcome of radioiodine therapy in thyroid cancer patients with recent contrasted computed tomography
Conclusion RIT in postthyroidectomy setting can be successfully performed within 90 days after CCT. Further research is needed to confirm our findings.
Authors: Okamura K, Bandai S, Fujikawa M, Sato K, Kitazono T Abstract The treatment of Graves' hyperthyroidism (GD) complicated with malignancy is challenging, as anti-thyroid thionamide drugs (ATDs) and anti-cancer chemotherapy are both associated with a risk of neutropenia. Treatment with conventional ATDs, radioactive iodine (RAI) or potassium iodide (KI) was attempted in 8 patients with malignancy (34-80 years of age; 2 males and 6 females) in whom GD had been fortuitously diagnosed during a detailed systematic examination. Three patients requiring surgery were initially treated conventionally with methylmercap...
CONCLUSIONS: In summary, by employing new long read sequencing methods, we were able to definitively demonstrate allele-specific DNA methylation, histone modifications, transcription factor binding, and the resulting mono-allelic transcription in cell lines with heterozygous TERT mutations. PMID: 32228178 [PubMed - as supplied by publisher]
CONCLUSIONS: The present study showed that specific RET-haplotypes, in particular haplotype 2 and the T-allele of p.Leu769=, are associated with a reduced risk of sMTC in Italians. PMID: 32228166 [PubMed - as supplied by publisher]
Authors: Lee YA, Im SW, Jung KC, Chung EJ, Shin CH, Kim JI, Park YJ Abstract Background Due to its very low prevalence, little is known about the genetic characteristics of pediatric follicular thyroid cancer (FTC). Methods We investigated genetic alterations in tumor tissues from 15 patients aged
CONCLUSIONS: Greater risk of BRAF-mutated papillary thyroid cancers among those with high BMI suggests that the association may not merely reflect greater healthcare service use and indicates an independent relationship between obesity and clinically important thyroid cancer. PMID: 32228152 [PubMed - as supplied by publisher]
CONCLUSION: Utilizing a large North American DTC registry, we found the prevalence of de novo TgAb detection to be 5% among initially TgAb negative patients. We did not find a statistically significant association between de novo TgAb development and DTC structural recurrence. Larger prospective studies are required to confirm these findings and further assess the significance of de novo TgAb detection in the follow up of DTC. PMID: 32228151 [PubMed - as supplied by publisher]
Thyroid, Ahead of Print.
ConclusionsWe found a lower risk of radiation-induced secondary malignancies in LFS breast cancer patients than previously reported in the literature (33% risk of radiation-induced sarcoma). These findings suggest that LFS may not be an absolute contraindication for radiotherapy in breast cancer. The potential risk for locoregional recurrence without radiotherapy must be weighed against the long-term risk for radiation-induced malignancies in consideration of adjuvant radiotherapy for LFS breast cancer patients.
Publication date: Available online 31 March 2020Source: Pathology - Research and PracticeAuthor(s): Zhe-Jia Zhang, Qian Xiao, Xin-Ying Li
Abstract Thyroid cancer (THCA) is a heterogeneous disease with multiple clinical outcomes Immune cells regulate its progression. Three immunomolecular subtypes (C1, C2, C3) were identified in gene expression data sets from TCGA and GEO databases. Among them, subtype C3 had highest frequency of BRAF mutations, lowest frequency of RAS mutations, highest mutation load and shorter progression-free survival. Functional enrichment analysis for the genes revealed that C1 was up-regulated in the ERK cascade pathway, C2 was up-regulated in cell migration and proliferation pathways, while C3 was enriched in body fluid, prot...