Development of an antibody cocktail for treatment of Sudan virus infection [Microbiology]

Antibody-based therapies are a promising treatment option for managing ebolavirus infections. Several Ebola virus (EBOV)-specific and, more recently, pan-ebolavirus antibody cocktails have been described. Here, we report the development and assessment of a Sudan virus (SUDV)-specific antibody cocktail. We produced a panel of SUDV glycoprotein (GP)-specific human chimeric monoclonal antibodies...

Source: Proceedings of the National Academy of Sciences - February 17, 2020 Category: Science Authors: Andrew S. Herbert, Jeffery W. Froude, Ramon A. Ortiz, Ana I. Kuehne, Danielle E. Dorosky, Russell R. Bakken, Samantha E. Zak, Nicole M. Josleyn, Konstantin Musiychuk, R. Mark Jones, Brian Green, Stephen J. Streatfield, Anna Z. Wec, Natasha Bohorova, Ognia Tags: Biological Sciences Source Type: research