Gut microbiota generation of protein-bound uremic toxins and related metabolites is not altered at different stages of chronic kidney disease.

Chronic kidney disease (CKD) is characterized by accumulation of protein-bound uremic toxins such as p-cresyl sulfate, p-cresyl glucuronide, indoxyl sulfate and indole-3-acetic acid, which originate in the gut. Intestinal bacteria metabolize aromatic amino acids into p-cresol and indole, (further conjugated in the colon mucosa and liver) and indole-3-acetic acid. Here we measured fecal, plasma and urine metabolite concentrations; the contribution of gut bacterial generation to plasma protein-bound uremic toxins accumulation; and influx into the gut of circulating protein-bound uremic toxins at different stages of CKD.

Source: Kidney International - February 17, 2020 Category: Urology & Nephrology Authors: Tessa Gryp, Kim De Paepe, Raymond Vanholder, Frederiek-Maarten Kerckhof, Wim Van Biesen, Tom Van de Wiele, Francis Verbeke, Marijn Speeckaert, Marie Joossens, Marie Madeleine Couttenye, Mario Vaneechoutte, Griet Glorieux Tags: Clinical Investigation Source Type: research