Interim response in diffuse large B cell lymphoma on CT: what is the optimal size reduction ( ΔSPD) for predicting outcome?

Conclusionsi ΔSPD with the cutoff value 80% is an independent predictor of PFS and OS for patients with DLBCL. Results suggest that treatment should be modified for patients with iΔSPD< 80%.Key Points• The aim of interim response assessment is to identify patients whose disease has not responded to or has progressed on induction therapy.• A cutoff value of 80% in size reduction (ΔSPD) is an independent predictor of PFS and OS for DLBCL patients and is better than 50%.• In DLBCL patients with interim ΔSPD< 80%, a change to a more efficient therapy should be considered.

Source: European Radiology - February 16, 2020 Category: Radiology Source Type: research