A Study of Patients With Chronic Disease

Conditions:   Asthma;   Chronic Obstructive Pulmonary Disease;   Idiopathic Pulmonary Fibrosis;   IPF;   COPD;   Respiratory Disease Intervention:   Sponsor:   Target PharmaSolutions, Inc. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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Eosinophils are associated with the onset of chronic respiratory diseases like asthma and COPD. In lung transplantation, patients with increased bronchoalveolar lavage eosinophils demonstrated a worse chronic lung allograft dysfunction (CLAD)-free survival and overall survival. We investigated the association between blood eosinophilia, graft survival and CLAD-free survival after lung transplantation.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (751) Source Type: research
Airway hyperresponsiveness (AHR) to direct stimuli is a characteristic feature of asthma and is thought to be due to airway smooth muscle dysfunction1. Patients with non-asthmatic chronic obstructive pulmonary disease (COPD) demonstrate AHR to direct stimuli (e.g. methacholine, histamine); this AHR correlates with the degree of airflow obstruction2-4 and is thought to be, in whole or in part, a function of altered airway geometry. We hypothesized that to the extent that AHR in COPD was due to geometric effect(s) of airflow obstruction, it would be less protected by acute treatment with beta agonist.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letters Source Type: research
by Kueiyu Joshua Lin, Evan Dvorin, Aaron S. Kesselheim BackgroundEvidence and guidelines do not support use of systemic steroids for acute respiratory tract infections (ARTIs), but such practice appears common. We aim to quantify such use and determine its predictors. Methods and findingsWe conducted a cohort study based on a large United States national commercial claims database, the IBM MarketScan, to identify patients aged 18 –64 years with an ARTI diagnosis (acute bronchitis, sinusitis, pharyngitis, otitis media, allergic rhinitis, influenza, pneumonia, and unspecified upper respiratory infections) recorded in a...
Source: PLoS Medicine - Category: Internal Medicine Authors: Source Type: research
ConclusionsHigh intensity interval training increases cardiorespiratory fitness and exercise capacity when compared with no exercise and produces a similar magnitude of change as continuous exercise in people with COPD. There is a paucity of studies exploring the effects of HIIT in other chronic pulmonary conditions.
Source: BMC Sports Science, Medicine and Rehabilitation - Category: Sports Medicine Source Type: research
Abstract Understanding the mechanisms that control the body's response to inflammation is of key importance, due to its involvement in myriad medical conditions, including cancer, arthritis, Alzheimer's disease and asthma. While resolving inflammation has historically been considered a passive process, since the turn of the century the hunt for novel therapeutic interventions has begun to focus upon active manipulation of constituent mechanisms, particularly involving the roles of apoptosing neutrophils, phagocytosing macrophages and anti-inflammatory mediators. Moreover, there is growing interest in how inflammat...
Source: Bulletin of Mathematical Biology - Category: Bioinformatics Authors: Tags: Bull Math Biol Source Type: research
If you ’re one of millions of Americans exposed to air pollution, you may be at a greater risk of catching the coronavirus — and of having a more severe infection.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Coronavirus (2019-nCoV) Air Pollution Respiratory Diseases Asthma Chronic Obstructive Pulmonary Disease Global Warming Environment Source Type: news
The underlying pathophysiological determinants of asthma and COPD are related in complex ways. Importantly however, post-bronchodilator forced expiratory volume in 1 s (FEV1) reversibility may occur in approximately 50% of COPD patients [1], whilst epidemiological [2] and magnetic resonance imaging (MRI) studies [3] suggest that, in asthma patients, FEV1 reversibility may diminish over time. As compared to patients with asthma or COPD alone, patients with co-existing asthma and COPD report worse clinical outcomes [4] and increased healthcare costs [5] and burden [4, 5].
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Original Articles: Research letters Source Type: research
Conditions:   Asthma;   COPD;   Exacerbation Copd;   Asthma; Eosinophilic;   Bronchial Diseases;   Lung Diseases, Obstructive;   Lung Diseases;   Immune System Diseases Interventions:   Drug: Azithromycin;   Drug: Placebo oral tablet Sponsors:   Bispebjerg Hospital;   Lund University;   University of Copenhagen;   Herlev and Gentofte Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
BOSTON (CBS) – As the coronavirus gains speed in Massachusetts, we are receiving a many health questions from viewers. Dr. Mallika Marshall answered some of the questions sent to WBZ-TV’s Facebook, Instagram and Twitter accounts. “Is there anything to having type A blood and being more prone to the coronavirus?” – Andrew, Facebook A preliminary study out of China suggests that people with type A blood may be at higher risk of being hospitalized from coronavirus compared to other blood groups. However, experts say this could be purely coincidental and urge people with type A...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health Healthwatch Syndicated Local Coronavirus Dr. Mallika Marshall Source Type: news
Asthma and COPD "overlap": a treatable trait or common several treatable-traits? Eur Ann Allergy Clin Immunol. 2020 Mar 19;: Authors: Gaspar Marques J, Lobato M, Leiria Pinto P, Neuparth N, Carreiro Martins P Abstract Summary: In the last years, disease classification of chronic respiratory diseases (CRD) has been vivaciously discussed and new concepts have been introduced, namely asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO). Controversially the GOLD consensus document of 2020 considered that we should no longer refer to ACO, as they constitute two different diseases that...
Source: European Annals of Allergy and Clinical Immunology - Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research
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