Safety and Immunogenicity of a Sabin Inactivated Poliovirus Vaccine

Condition:   Polio Interventions:   Biological: sIPV;   Biological: Commercialized sIPV;   Biological: Commercialized IPV Sponsors:   Jiangsu Province Centers for Disease Control and Prevention;   Beijing Minhai Biotechnology Co., Ltd Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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Authors: Schlipköter U, Flahault A Abstract The past two centuries have seen enormous achievements in control of infectious diseases, previously the leading cause of death, in large measure due to sanitation and food safety, vaccines, antibiotics and improved nutrition. This has led people to put their faith in the notion that medical science would succeed in overcoming the remaining obstacles. Vaccination has eradicated smallpox, nearly eradicated poliomyelitis and greatly reduced many other highly dangerous infections such as diphtheria, tetanus and measles. New diseases such as HIV and new forms of influenz...
Source: Public Health Reviews - Category: International Medicine & Public Health Tags: Public Health Rev Source Type: research
The odd hush that has fallen over New York City has lately been broken once every day, at precisely 7:00 PM. That’s when New Yorkers are stepping onto balconies or flinging open windows to applaud the people—pharmacy clerks, supermarket cashiers, food delivery workers and more—who continue to keep to keep the silent city running. But even the most heroic of health-care workers are faced with a difficult reality in the city that has become the center of COVID-19 in the U.S., as officials have predicted that New York City will need at least 400 more ventilators by Sunday and thousands more in the days to fo...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 Source Type: news
by Concepcion F. Estivariz, Sarah D. Bennett, Jacquelyn S. Lickness, Leora R. Feldstein, William C. Weldon, Eva Leidman, Daniel C. Ehlman, Muhammad F. H. Khan, Jucy M. Adhikari, Mainul Hasan, Mallick M. Billah, M. Steven Oberste, A. S. M. Alamgir, Meerjady D. Flora BackgroundWe performed a cross-sectional survey in April –May 2018 among Rohingya in Cox’s Bazar, Bangladesh, to assess polio immunity and inform vaccination strategies. Methods and findingsRohingya children aged 1 –6 years (younger group) and 7–14 years (older group) were selected using multi-stage cluster sampling in makeshift settlemen...
Source: PLoS Medicine - Category: Internal Medicine Authors: Source Type: research
Right now, many people are hoping for a vaccine to protect against the new coronavirus. While that’s still on the horizon, new research suggests that families who do vaccinate their children may not be following the recommended schedule. Vaccines are given on a schedule for a reason: to protect children from vaccine-preventable disease. Experts designed the schedule so that children get protection when they need it — and the doses are timed so the vaccine itself can have the best effect. When parents don’t follow the schedule, their children may not be protected. And yet, many parents do not follow the sc...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Adolescent health Children's Health Parenting Vaccines Source Type: blogs
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Source: Human Vaccines and Immunotherapeutics - Category: Allergy & Immunology Authors: Source Type: research
Dr. Bruce Aylward has almost 30 years experience in fighting polio, Ebola and other diseases, and now, he’s turned his attention to stopping the spread of COVID-19. Aylward, the senior adviser to the Director-General of the World Health Organization (WHO), is one of the world’s top officials in charge of fighting the coronavirus pandemic. The doctor, who led a joint WHO mission to China in February to study the effectiveness of the coronavirus response in the country, has seen firsthand the measures Beijing took to fight the virus. Now he’s sharing what he learned with governments and communicating with t...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 overnight Source Type: news
Dr. Bruce Aylward has almost 30 years experience in fighting polio, Ebola and other diseases, and now, he’s turned his attention to stopping the spread of COVID-19. Aylward, the senior adviser to the Director-General of the World Health Organization (WHO), is one of the world’s top officials in charge of fighting the coronavirus pandemic. The doctor, who lead a joint WHO mission to China in February to study the effectiveness of the coronavirus response in the country, has seen firsthand the measures Beijing took to fight the virus. Now he’s sharing what he learned with governments and communicating with ...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 overnight Source Type: news
Abstract The efficacy of a Sabin-derived inactivated polio vaccine (sIPV) can be evaluated by measuring the immunogenicity and the contents of D-antigens, which induce the neutralizing antibodies. The immunogenic potency test in rats was done as a national assay in Japan. The two manufacturers of sIPV in Japan have performed both assays since development, and there is no clear discrepancy between the results obtained in the two assays. To further know the relationship between the two assays, we analyzed the effects of the heat treatment of sIPV on the D-antigenicity and the immunogenicity. We observed that the mar...
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
If we get a vaccine for the coronavirus, it will immediately make our world a safer, easier, more reassuring place once again. That ’s what vaccines do.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Vaccination and Immunization Coronavirus (2019-nCoV) Children and Childhood Quarantines Smallpox Poliomyelitis Influenza Epidemics Source Type: news
Chelsea FollettThe pandemic caused by the new coronavirus (COVID-19) from Wuhan, China, is now a serious and global problem. And that problem has been made even worse by a culture of constant alarmism making it hard to distinguish real threats from exaggerated claims, as the well ‐​known science writer Matt Ridley has pointed out. But even when faced with the genuine threat of a pandemic, there are reasons to take heart and think that humanity will rise to the challenges ahead.First, humanity has never been better prepared technologically to deal with a pandemic. We are fortunate to live in an age o...
Source: Cato-at-liberty - Category: American Health Authors: Source Type: blogs
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