Vps34 derived phosphatidylinositol 3-monophosphate  modulates megakaryocyte maturation and proplatelet production through late endosomes/lysosomes.

CONCLUSION: Our results suggest that PI3P-positive LE/Lys contribute to the membrane growth and proplatelet formation in MKs by their translocation to the cell periphery and fusion with the plasma membrane.
PMID: 32056354 [PubMed - as supplied by publisher]

Source: Thrombosis and Haemostasis - February 12, 2020 Category: Hematology Authors: Bertović I, Kurelić R, Milošević I, Bender M, Krauss M, Haucke V, Jurak Begonja A Tags: J Thromb Haemost Source Type: research