Long-term outcome and pre-interventional predictors for late intervention after uterine fibroid embolization

Uterine leiomyomas are the most common benign tumors of the uterus with a premenopausal cumulative clinically relevant incidence of 50% in black and 35% in white women [1]. The standard treatment for symptomatic fibroids is hysterectomy, but there has been a shift towards less invasive approaches like myomectomy, high intensity focused ultrasound and UFE [1 –3]. Mid- and long-term studies evaluating therapy effectiveness after UFE suggest freedom from treatment failure between 70%-90%, based on follow-up times between 1 and 10 years [2,3,5–9]; however, follow-up data longer than 10 years after UFE are scarce as well as preinterventional factors predicting higher risk for treatment failure and late conversion to surgery.
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - Category: OBGYN Authors: Tags: Review article Source Type: research

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Authors: Mangano A, Valle V, Bustos R, Gruessner S, Masrur M, Aguiluz G, Bianco F, Giulianotti PC Abstract Uterine leiomyomata are the most frequent leiomyomata. However, this benign tumor can also arise in unusual locations (e.g. ovaries, urethra, bladder and vulva). The diagnostic process of ovarian leiomyomata can be difficult, and it is mostly incidental: the lesions are usually small and the clinical presentation is mainly asymptomatic. Since the first case described in 1862, less than 100 cases have been described. Some of these lesions have been treated laparoscopically. To our knowledge, this is the first w...
Source: Minerva Chirurgica - Category: Surgery Tags: Minerva Chir Source Type: research
We present 3 cases of extrapulmonary lymphangioleiomyomatosis (LAM) identified incidentally in the uterine corpus and pelvic nodes resected for other reasons. One patient, a 47-yr-old female with corpus cancer, underwent a total hysterectomy and nodal dissection; the other 2 patients, aged 44 and 49 yr, underwent simple hysterectomy for corpus leiomyomas. None of the patients had evidence of tuberous sclerosis complex or any significant lesions in other organs. An area of spindle cell proliferation, intimately associated with dilated and tortuous lymphatic vessels, was found in the myometrium of all 3 patients, and ...
Source: International Journal of Gynecological Pathology - Category: Pathology Tags: PATHOLOGY OF THE CORPUS: CASE REPORTS Source Type: research
Extragonadal pelvic yolk sac tumor (YST) in postpubertal female patients is a rare malignant neoplasm with potentially 2 distinct histogenetic pathways, and no clear treatment algorithm, especially in young patients desiring future fertility. Here we report a case of extragonadal YST arising within the myometrium in a 30-yr-old nulligravid woman. The patient presented with heavy and irregular bleeding, and imaging studies showed an 8.2 cm uterine mass, most consistent with a degenerating uterine leiomyoma. The patient underwent abdominal myomectomy, and intraoperative frozen section evaluation revealed a high-grade ...
Source: International Journal of Gynecological Pathology - Category: Pathology Tags: PATHOLOGY OF THE CORPUS: CASE REPORTS Source Type: research
Publication date: Available online 1 April 2020Source: Urology Case ReportsAuthor(s): Kian Asanad, Daphne Remulla, Nima Nassiri, Saum Ghodoussipour
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
We report the RNAseq data from uterine tissues obtained from mice that over-express KRAS-G12D or KRAS-G12V oncogenes in a Ahmr2-Cre Pten null genetic background.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
AbstractLeiomyomatosis is a uterine condition that can rarely present with extrauterine involvement. Intravenous and intracardiac extensions are extremely rare presentations and, in these cases, the intra ‐cardiac mass may be confused with a cardiac myxoma and can be associated with pulmonary embolism. Here we report two cases of successful surgically removed intracardiac leiomyomas under cardiopulmonary bypass.
Source: Journal of Cardiac Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: SURGICAL TECHNIQUE Source Type: research
We present the case of a 40-year-old woman with a primary intraventricular leiomyoma. She consulted us for headache, dizziness, and black spots in her vision. Magnetic resonance images (MRI) disclosed a mass rooted in the posterior septum pellucidum. The tumor was totally excised by the senior author with no residual seen on intraoperative MRI. Pathological examination showed it to be a benign spindle-cell neoplasm. On the 6th month control MRI, there was no recurrence. We also reviewed articles relevant to primary intracranial leiomyomas.
Source: Neurosurgical Review - Category: Neurosurgery Source Type: research
Single-incision laparoscopic surgery (SILS) is an exciting new modality in the field of minimal access surgery that provides the advantage of further reducing the number of scars of standard laparoscopy. While there are case reports of single incision laparoscopic surgery for adnexal pathology in this population, there are none in regards to treatment of uterine pathology such as leiomyoma. This case illustrates the feasibility of single incision laparoscopic surgery for uterine pathology in the pediatric and adolescent population.
Source: Journal of Pediatric and Adolescent Gynecology - Category: OBGYN Authors: Source Type: research
Diffuse leiomyomatous disease is a rare manifestation of Alport Syndrome. When identified, it has been associated with symptoms of reflux and dysphagia secondary to esophageal disease. There is scant published literature on genitourinary complaints in female patients with Alport Syndrome found to have leiomyomata in the genital tract outside of the uterine cavity.
Source: Journal of Pediatric and Adolescent Gynecology - Category: OBGYN Authors: Source Type: research
Endoscopy DOI: 10.1055/a-1130-6098 © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text
Source: Endoscopy - Category: Gastroenterology Authors: Tags: E-Videos Source Type: research
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