Cholesterol Drugs Might Help Curb'High-Risk' Prostate Cancers

FRIDAY, Feb. 14, 2020 -- Drugs that many men with prostate cancer might already be taking -- cholesterol-lowering statins -- may help extend their survival if they have a " high-risk " form of the disease, new research suggests. High-risk patients...
Source: - Daily MedNews - Category: General Medicine Source Type: news

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AbstractIn castration-resistant prostate cancer (CRPC) patients, observational studies have reported that statins may boost the antitumor activity of abiraterone (AA) and data suggest an improvement in efficacy; conclusions with vitamin D are less clear but an eventual benefit has been pointed. We conducted a post hoc analysis of individual patient data of CRPC patients treated with prednisone and/or AA with or without statins/vitamin D on randomized clinical trials. In the COU-AA-301 trial, use of AA with statin and vitamin D reduced the risk of death by 38% (p = 0.0007) while AA alone was associated with a ...
Source: Clinical and Translational Oncology - Category: Cancer & Oncology Source Type: research
AbstractPurpose of ReviewTo discuss the overall and latest observations of the effect of diet, lifestyle, supplements, and some prescription heart healthy medications for prostate cancer prevention.Recent FindingsThe concept of maximizing heart health to prevent aggressive prostate cancer continues to be solidified with the addition of more prospective observational and randomized controlled trial data. Heart healthy is prostate healthy, and heart unhealthy is prostate unhealthy.SummaryThe primary goal of reducing the risk of all-cause and cardiovascular disease (CVD) morbidity and mortality also coincides with maximizing ...
Source: Current Urology Reports - Category: Urology & Nephrology Source Type: research
The use of statins, alone or in combination with metformin, was found to be associated with lower all-cause and prostate cancer mortality among high-risk patients, particularly in post-diagnostic settings.
Source: CancerNetwork - Category: Cancer & Oncology Authors: Source Type: news
FRIDAY, Feb. 28, 2020 -- Statin use alone or in combination with metformin is associated with lower all-cause and prostate cancer (PCa) mortality among high-risk patients, according to a study published online Feb. 8 in Cancer Medicine. Xiang-Lin...
Source: - Pharma News - Category: Pharmaceuticals Source Type: news
The study couldn't prove cause and effect, but it found that statins, taken alone or with metformin, did seem associated with an increase in survival.
Source: WebMD Health - Category: Consumer Health News Source Type: news
ConclusionsStatin use alone or in combination with metformin was associated with lower all ‐cause and PCa mortality among high‐risk patients, particularly in post‐diagnostic settings; further studies are warranted.
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
(Thomas Jefferson University) Statin use alone or with metformin is associated with lower prostate cancer mortality from all causes, among high-risk patients.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
Prostate Cancer and Prostatic Diseases, Published online: 06 February 2020; doi:10.1038/s41391-020-0207-5Associations among statins, preventive care, and prostate cancer mortality
Source: Prostate Cancer and Prostatic Diseases - Category: Urology & Nephrology Authors: Source Type: research
Telephone intervention linked to rise in men ’s vegetable consumption but not to drop in risk of progression Related items fromOnMedica Less regular PSA screening puts men at risk NICE guidance delays hinder good diabetes care Population weight control best for cutting diabetes prevalence Starting statins not beneficial in many older adults NHS must hold CCGs accountable for poor diabetes care
Source: OnMedica Latest News - Category: UK Health Source Type: news
ConclusionMetformin and statins were not associated with BFFS or DFFS improvement in our analysis. However, the small number of patients treated with these drugs limits the reliability of the results and prospective studies are needed.
Source: Reports of Practical Oncology and Radiotherapy - Category: Cancer & Oncology Source Type: research
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