Antimicrobial activity of Lactobacillus fermentum TcUESC01 against Streptococcus mutans UA159

Publication date: Available online 12 February 2020Source: Microbial PathogenesisAuthor(s): Jeisa Zielle de Souza Rodrigues, Manuela Ribeiro Passos, Nayara Silva de Macêdo Neres, Rafael Silva Almeida, Louise Soares Pita, Iago Almeida Santos, Paulo Henrique Santana Silveira, Mariane Mares Reis, Isabella Porto Santos, Luccas de Oliveira Negrão Ricardo, Brenda Oliveira Lima, Patrick D'Orleans Farias Marinho, Ananda Brito Soares, Leonardo Oliveira Silva Bastos Andrade, Stela Mares Brasileiro Pessoa, Marlon Mário Leles Silva, Milena Cardoso Oliveira, Jamile Pinheiro da Silva, Mariana Araújo Moura, Mariluze Peixoto CruzAbstractDental caries is a multifactorial chronic-infection disease, which starts with a bacterial biofilm formation caused mainly by Streptococcus mutans. The use of probiotics has shown numerous health benefits, including in the fight against oral diseases. Strains of Lactobacillus fermentum have already shown probiotic potential against S. mutans, but there are still few studies. Thus, the aim of our study was to evaluate the antimicrobial activity of the inoculum and metabolites produced by L. fermentum TcUESC01 against S. mutans UA159. For this, a growth curve of L. fermentum was performed and both the inoculum and the metabolites formed in the fermentation were tested against the growth of S. mutans UA159 in agar diffusion tests, and only its metabolites were tested to determine the minimum inhibitory concentration, minimal bactericidal concentration and in...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research