Nuocytes from mesenteric lymph node promote allergic responses in a mouse model

ConclusionThe findings demonstrate that nuocytes from the mesenteric lymph nodes of wild-type mice promote allergic responses in a mouse model.ResumoIntroduçãoOs nuócitos desempenham um papel importante na imunidade do tipo 2. No entanto, a contribuição das interleucinas ILC2s na rinite alérgica ainda precisa ser elucidada.ObjetivoAvaliar o papel dos nuócitos de linfonodos mesentéricos nas respostas alérgicas em camundongos.MétodoApós a administração intraperitoneal de interleucina (IL)-25 e IL-33 em camundongos do tipo selvagem e camundongos Il17br−/−Il1rl1−/− com deficiência dupla, os nuócitos foram purificados do tecido linfoide associado a mucosa nasal e linfonodos mesentéricos. Em seguida, avaliamos as produções de IL-5 e IL-13 em culturas de nuócitos. Finalmente, transferimos adotivamente os nuócitos derivados de linfonodos mesentéricos de camundongos do tipo selvagem e camundongos Il17br−/−Il1rl1−/− para o modelo murino de rinite alérgica para avaliar seu papel nas respostas alérgicas nasais.ResultadosMostramos que os nuócitos nos linfonodos mesentéricos de camundongos do tipo selvagem estavam upregulados após a aplicação de IL-25 e IL-33 e foram induzidos a produzir IL-5 e IL-13. Osespirros e fricção nasal, bem como...
Source: Brazilian Journal of Otorhinolaryngology - Category: ENT & OMF Source Type: research

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Publication date: Available online 13 February 2020Source: Journal of Microbiology, Immunology and InfectionAuthor(s): Cheryn Yu Wei Choo, Kuo-Wei Yeh, Jing-Long Huang, Kuan-Wen Su, Ming-Han Tsai, Man-Chin Hua, Sui-Ling Liao, Shen-Hao Lai, Li-Chen Chen, Chih-Yung ChiuAbstractBackgroundThe association between oxidative stress and atopic diseases is uncertain. Several risk factors for atopic diseases have been identified, however, a comprehensive investigation of the relationship between oxidative stress markers and atopic indices related to atopic diseases is currently lacking.MethodsWe investigated 132 children who complet...
Source: Journal of Microbiology, Immunology and Infection - Category: Microbiology Source Type: research
Type I allergic hypersensitivity disorders (atopy) including asthma, atopic dermatitis, allergic rhinitis, and food allergy are on the rise in developed and developing countries. Engineered nanomaterials (ENMs) span a large spectrum of material compositions including carbonic, metals, polymers, lipid-based, proteins, and peptides and are being utilized in a wide range of industries including healthcare and pharmaceuticals, electronics, construction, and food industry, and yet, regulations for the use of ENMs in consumer products are largely lacking. Prior evidence has demonstrated the potential of ENMs to induce and/or agg...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
CONCLUSION: Drug therapy or drug therapy combined with psychological intervention can alleviate anxiety and depression of patients with persistent moderate-severe allergic rhinitis and improve their quality of life. Moreover, based on the effect of improving mental disorder and quality of life of patients, drug therapy combined with psychological intervention is better than drug treatment alone. PMID: 32050792 [PubMed - as supplied by publisher]
Source: Ear, Nose and Throat Journal - Category: ENT & OMF Authors: Tags: Ear Nose Throat J Source Type: research
We describe our experiment using a quantum dot-based lateral flow immunoassay combined with a portable fluorescence immunoassay chip detector for both qualitative and quantitative detection of serum-specific IgE against two common mite allergens. This strategy can be applied at home, in hospitals, and in pharmacies, with reduced costs and time requirements. In the future, this system could be developed to detect other types of allergens and in different types of samples. PMID: 32052065 [PubMed - as supplied by publisher]
Source: Analytical and Bioanalytical Chemistry - Category: Chemistry Authors: Tags: Anal Bioanal Chem Source Type: research
Correction to:Allergo J Int 2019https://doi.org/10.1007/s40629-019-00110-9Affiliation and disclaimer have been misrepresented and are hereby corrected:Vera  Mahler:Affiliation: Med. Faculty, Friedrich-Alexander-University (FAU) Erlangen-N ürnberg, Germany.Disclaimer: The views expressed in this …
Source: Allergo Journal International - Category: Allergy & Immunology Source Type: research
Condition:   Rhinitis, Allergic Interventions:   Drug: Azelastine hydrochloride (BAYR9258);   Drug: Placebo Sponsor:   Bayer Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Allergic rhinitis (AR) is believed to be a complex genetic disease. The last decade has been marked by the publication of more than 20 genome-wide association studies (GWASs) of AR and associated allergic phen...
Source: Allergy, Asthma and Clinical Immunology - Category: Allergy & Immunology Authors: Tags: Research Source Type: research
This study is part of the European Community Respiratory Health Survey (ECRHS). A random adult population from 25 centres in Europe and one in Australia was examined with spirometry and answered a respiratory questionnaire in 1998 –2002 (ECRHS II) and in 2008–2013 (ECRHS III). Symptoms of non-infectious rhinitis, hay fever and asthma, and smoking habits were reported. Subjects reporting asthma were excluded. COPD was defined as a spirometry ratio of FEV1/FVC  
Source: European Archives of Oto-Rhino-Laryngology - Category: ENT & OMF Source Type: research
RARITAN, NJ, February 10, 2020 – The Janssen Pharmaceutical Companies of Johnson &Johnson announced today the submission of a supplemental Biologics License Application (sBLA) to the U.S. Food and Drug Administration (FDA) seeking approval of DARZALEX® (daratumumab) in combination with Kyprolis® (carfilzomib) and dexamethasone (DKd) for relapsed/refractory multiple myeloma. The sBLA is supported by results from the Phase 3 CANDOR study, which compared treatment with DKd to carfilzomib and dexamethasone (Kd) in patients with multiple myeloma who relapsed after one to three prior lines of therapy. “Wh...
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Innovation Source Type: news
Acupoint application therapy (AAT) has been widely used to treat allergic inflammation induced by allergic rhinitis (AR). The therapeutic effect of acupoint application is obvious. But the underlying therapeut...
Source: Journal of Inflammation - Category: Allergy & Immunology Authors: Tags: Research Source Type: research
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