Lipid-based nanosystem as intelligent carriers for versatile drug delivery applications.

LIPID-BASED NANOSYSTEM AS INTELLIGENT CARRIERS FOR VERSATILE DRUG DELIVERY APPLICATIONS.
Curr Pharm Des. 2020 Feb 05;:
Authors: Harshita, Barkat MA, Das SS, Pottoo FH, Beg S, Rahman Z
Abstract
The contemporary drug discovery research shows that the most of the drug candidates are highly potent but showing poor aqueous solubility leads a variety of challenges for formulation scientists to develop a suitable formulation to improve the systemic bioavailability of such drugs. Lipid based nanocarriers act as a major and most projecting approach overcoming the limitations which affects several physiochemical properties of drug such as the solubility, partition coefficient and bioavailability or absorption. This also fulfill a variety of product requirements and helps to overcome several limitations as decided by symptoms of disease, various route of administration of drug, price concern, increasing strength of product, noxious or harmful effect of drug, and dose efficacy. The lipidic nanosystem is very helpful to formulate aqueous drug in lipid base and also commercially feasible approach for the formulation of different dosage form meant for topical or transdermal, oral, ocular, pulmonary, and parenteral delivery. This review provides a brief on lipid based drug delivery nanocarrier and the mechanisms by which lipids and lipidic excipients improve the oral absorption of drugs with poor aqueous solubility and also provides a viewpoint on t...

Source: Current Pharmaceutical Design - February 4, 2020 Category: Drugs & Pharmacology Authors: Harshita, Barkat MA, Das SS, Pottoo FH, Beg S, Rahman Z Tags: Curr Pharm Des Source Type: research