Single-cell transcriptome analysis of human skin identifies novel fibroblast subpopulation and enrichment of immune subsets in atopic dermatitis

Single-cell transcriptomic profiling of AD reveals distinct compositional and cell-specific gene expression changes, and a novel inflammatory fibroblast subpopulation that may orchestrate T-cell migration/trafficking and type 2 immune responses.

Source: Journal of Allergy and Clinical Immunology - February 5, 2020 Category: Allergy & Immunology Authors: Helen He, Hemant Suryawanshi, Pavel Morozov, Jes ús Gay-Mimbrera, Ester Del Duca, Hyun Je Kim, Naoya Kameyama, Yeriel Estrada, Evan Der, James G. Krueger, Juan Ruano, Thomas Tuschl, Emma Guttman-Yassky Source Type: research