Evaluation of intradialytic sodium shifts during sodium controlled hemodialysis.

Evaluation of intradialytic sodium shifts during sodium controlled hemodialysis. Int J Artif Organs. 2020 Feb 04;:391398820903055 Authors: Ponce P, Pinto B, Wojke R, Maierhofer AP, Gauly A Abstract Plasma sodium shifts during hemodialysis treatments can be minimized by application of a sodium control algorithm. The present randomized cross-over trial was designed to apply this option on a large patient cohort and to observe the time course of plasma sodium over the treatment. In one study phase, patients received post-dilution online hemodiafiltration treatments with sodium control over the entire treatment. In the other study phase, patients received isolated ultrafiltration during the first 90 min followed by post-dilution online hemodiafiltration with sodium control for the remainder of the session, with the purpose to follow a possible initial equilibration process without the influence of a diffusive solute transfer. Each phase included six treatments and was delivered in randomized order. Eighty-one patients were enrolled, 77 patients could be analyzed as intention-to-treat population. The difference of the mean plasma sodium concentration between start and end of the treatment was -0.60 mmol/L (confidence interval -0.88 to -0.32) and -0.15 mmol/L (confidence interval -0.43 to 0.13), for sodium control and isolated ultrafiltration during the first 90 min followed by post-dilution online hemodiafiltration with sodium con...
Source: The International Journal of Artificial Organs - Category: Transplant Surgery Authors: Tags: Int J Artif Organs Source Type: research