On the concepts of dose-mean lineal energy, unrestricted and restricted dose-averaged LET in proton therapy.

CONCLUSIONS: Unrestricted LETd, restricted LETd and y_D can be analytically computed and compared for clinical plans. Two important consequences of the calculation of y_D are: 1) its distribution can be verified by directly measuring it in clinical beams; and 2), optimization of proton treatments based on these quantities is enabled as well as future developments of RBE models based on them.
PMID: 32023557 [PubMed - as supplied by publisher]

Source: Physics in Medicine and Biology - February 4, 2020 Category: Physics Authors: Bertolet A, Cortes-Giraldo MA, Carabe A Tags: Phys Med Biol Source Type: research