Nocturnal light exposure stimulates the cardiac fibrinolysis system and stress responses in C3H/He mice

Plasminogen activator inhibito-1 (PAI-1) is a primary physiological inhibitor of tissue plasminogen activator (tPA) and the major inhibitor of fibrinolysis [1]. Tissue factor (TF) plays a crucial role at the beginning of the coagulation pathway in initiating the formation of a thrombus and blood coagulation, and is prothrombotic [1]. The serine protease, tPA activates plasmin, a promoter of fibrin degradation. Elevated circulating PAI-1 levels are associated with an increased risk of myocardial infarction, and PAI-1 has been suggested to be the protein most involved in regulating the fibrinolytic system [2].

Source: Thrombosis Research - February 4, 2020 Category: Hematology Authors: Michiko T. Yasuda, Yuto Watanabe, Takashi Hosono, Taiichiro Seki, Taka-aki Suzuki, Hiroyuki Sakakibara, Kayoko Shimoi Tags: Letter to the Editors-in-Chief Source Type: research