The Biology of Lung Cancer: Development of More Effective Methods for Prevention, Diagnosis, and Treatment.

The Biology of Lung Cancer: Development of More Effective Methods for Prevention, Diagnosis, and Treatment.
Clin Chest Med. 2020 Mar;41(1):25-38
Authors: Salehi-Rad R, Li R, Paul MK, Dubinett SM, Liu B
Abstract
Lung cancer is a heterogeneous disease with abundant genomic alterations. Chronic dysregulated airway inflammation facilitates lung tumorigenesis. In contrast, antitumor host immune responses apply continuous selective pressure on the tumor cells during the evolutionary course of the disease. Unprecedented advances in integrative genomic, epigenomic, and cellular profiling of lung cancer and the tumor microenvironment are enhancing the understanding of pulmonary tumorigenesis. This understanding in turn has led to advancements in lung cancer prevention and early detection strategies, and the development of effective targeted therapies and immunotherapies with survival benefit in selected patients.
PMID: 32008627 [PubMed - in process]

Source: Clinical Lung Cancer - February 5, 2020 Category: Cancer & Oncology Authors: Salehi-Rad R, Li R, Paul MK, Dubinett SM, Liu B Tags: Clin Chest Med Source Type: research