Proteins Marker Could Identify Aggressive Lung Cancers

A specific pair of proteins more often found in aggressive smoking-related lung adenocarcinomas could serve as a prognostic biomarker for aggressive disease.
Source: Cancer Network - Category: Cancer & Oncology Source Type: news

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Authors: Latorzeff I Abstract Prostate cancer is a sensitive adenocarcinoma, in more than 80 % of cases, to chemical castration, due to its hormone dependence. Locally advanced and/or high-risk cancer is defined based on clinical stage, initial PSA value or high Gleason score. Hormone therapy associated with radiation therapy is the standard of management and improves local control, reduces the risk of distant metastasis and improves specific and overall survival. Duration of hormone therapy, dose level of radiation therapy alone or associated with brachytherapy are controversial data in the literature. Radical pro...
Source: Progres en Urologie - Category: Urology & Nephrology Tags: Prog Urol Source Type: research
Publication date: October 2019Source: Biomedicine &Pharmacotherapy, Volume 118Author(s): Shenghu Guo, Yuehua Zhang, Zheng Wu, Lei Zhang, Dongwei He, Xing Li, Zhiyu WangAbstractLung cancer remains the leading cause of cancer associated deaths worldwide. Recent efforts have been focused on combinational and nanoparticulate therapies that can efficiently deliver multiple therapeutics. Herein, we reported cetuximab (CET) functionalized, paclitaxel (PTX) and 5-Demethylnobiletin (DMN) co-loaded nanostructured lipid carriers (NLCs) (CET-PTX/DMN-NLCs). The morphology, particle size, zeta potential, stability and drug release w...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 16 July 2019Source: The Annals of Thoracic SurgeryAuthor(s): Tamar Nobel, Jennifer Livschitz, Xin Xin Xing, Meier Hsu, Kay See Tan, Arianna Barbetta, Smita Sihag, David Jones, Daniela MolenaAbstractBackgroundThere are limited data regarding optimal surveillance after curative resection for esophageal cancer. Once disease recurrence is diagnosed, the prognosis is poor. The purpose of this paper was to characterize disease recurrence in patients with early esophageal adenocarcinoma (EAC).MethodsThere were 260 patients identified from a prospective institutional database with pathologic T1 a...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Conclusions: Our observations may point to the potential prognostic significance of MT2 in NSCLC.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
ConclusionBased on the cohort investigated, our data suggested that systemic proteome alterations involved in pathways associated with inflammation, immunoresponse, coagulation and complement cascades may be reporters of chemo-treatment outcome in PDAC patients. For the majority of the patients involved, the panel consisting of PZ, SHBG, VWF and CA 19-9 was able to segregate Good-responders from Limited-responders effectively. Our data also showed that dramatic fluctuations of biomarker concentration in the circulating system of a PDAC patient, which might result from biological heterogeneity or confounding complications, ...
Source: Clinical Proteomics - Category: Biochemistry Source Type: research
Dr Michael G. House (Indianapolis, IN): I would like to congratulate Dr Sweigert for the very easy, organized study and a very beautiful presentation. I think under the mentorship of Dr Marshall Baker, you have done a very nice analysis of patients with invasive gastric adenocarcinoma who were captured by the National Cancer Database. You focused on patients who underwent total gastrectomy. It's a large-scale study. It obviously had appropriate propensity matching between the surgical treatment groups, namely, those who underwent minimally invasive technique for total gastrectomy and those who underwent an open operation.
Source: Surgery - Category: Surgery Source Type: research
ConclusionsCases harbouring targetable genetic variants had a higher risk of recurrence, but PRS was prolonged by TKI therapy. Classification according to the targetable genetic status provides a basis for predicting recurrence and determining treatment strategies after recurrence.
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research
Conclusion.Apatinib monotherapy showed promising efficiency for patients with refractory colorectal cancer, especially in patients with PS 0–1 or no liver metastasis. ctDNA abundance may be a predictor in serial monitoring of tumor load.
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Chinese Edition, Clinical Trial Results, Gastrointestinal Cancer Source Type: research
Conclusion: SEMS effectively reduced dysphagia in inoperable esophageal cancer. Better survival rates were observed in females than males.
Source: Indian Journal of Palliative Care - Category: Palliative Care Authors: Source Type: research
Conclusion.Our modeling analysis suggests that nFOLFIRINOX is preferable to upfront surgery for patients with BR/LA PDAC from both an effectiveness and cost‐effectiveness standpoint. Additional clinical data that further define the long‐term effectiveness of nFOLFIRINOX are needed to confirm our results.Implications for Practice.Increasingly, neoadjuvant FOLFIRINOX has been used for borderline resectable and locally advanced pancreatic cancer with the goal of rendering them resectable and decreasing risk of recurrence. Despite many efforts to show the benefits of neoadjuvant over adjuvant therapies, clinical evidence t...
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Health Outcomes and Economics of Cancer Care, Gastrointestinal Cancer Source Type: research
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