γ-C(sp3)-H bond functionalisation of α,β-unsaturated amides through an umpolung strategy

Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00125B, CommunicationMasafumi Ueda, Norihiko Takeda, Erika Futaki, Motohiro Yasui, Tetsuro Shinada, Okiko Miyata The nucleophilic γ-phenylation and γ-alkylation of α,β-unsaturated amides have been developed. This umpolung reaction allows the regioselective introduction of phenyl and alkyl groups to a vinylketeneN,O-acetal, which is generated in... The content of this RSS Feed (c) The Royal Society of Chemistry

Source: RSC - Organic and Biomolecular Chemistry - February 3, 2020 Category: Molecular Biology Authors: Masafumi Ueda Source Type: research