Mechanisms of Altered Renal Microvascular Function in Type 1 Diabetes: Potential Contribution to End Organ Damage.

Mechanisms of Altered Renal Microvascular Function in Type 1 Diabetes: Potential Contribution to End Organ Damage. Curr Vasc Pharmacol. 2013 Sep 25; Authors: Carmines PK Abstract Although diabetes mellitus is the primary cause of end stage renal disease, the mechanisms underlying the initiation and progression of diabetic nephropathy are not well understood. The widely accepted opinion holds that events occurring early during the course of diabetes engender the progression of diabetic nephropathy. Diabetic hyperglycemia exerts an array of direct and indirect influences on the renal preglomerular microvasculature, as well as on glomeruli and tubular epithelial cells. Although the scope of these effects is not yet fully recognized, alterations in the myogenic and tubuloglomerular feedback responses, electromechanical coupling in preglomerular vascular smooth muscle, and interactions between tubular transport and vascular function all contribute to renal vascular dysfunction early after onset of T1D. These changes, which arise in environment conducive to oxidative stress and inflammation, are thought to either initiate or facilitate the eventual development of diabetic nephropathy in susceptible individuals. PMID: 24066931 [PubMed - as supplied by publisher]
Source: Current Vascular Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Vasc Pharmacol Source Type: research