The value of prostate-specific antigen monitoring during salvage radiotherapy: a retrospective study and systematic review with meta-analysis

ConclusionThese results need confirmation using prospective data before being applied to clinical practice and could help physician to choose the correct therapeutic strategy.
Source: Journal of Radiation Oncology - Category: Cancer & Oncology Source Type: research

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Radiation therapy (RT) is part of definitive treatment for patients with unresectable non-small cell lung cancer (NSCLC). Despite major technological advances in imaging and conformal delivery techniques, the tolerances of adjacent normal tissues continue to limit target volume doses [1,2]. In patients receiving RT for thoracic malignancies, the most frequent toxicities occur in the lungs and/or heart. Radiation-induced cardiac toxicity (RICT) may present as multiple pathologies including myocardial fibrosis, ischemic heart disease, valvular abnormalities and pericarditis [3].
Source: Radiotherapy and Oncology - Category: Radiology Authors: Tags: Original Article Source Type: research
Multiple forms of definitive radiotherapy are acceptable alternatives to more prolonged radiotherapy regimens for men with intermediate-risk prostate cancer (PCa) and can be considered for men with low-risk disease who decline active surveillance.[1] Stereotactic body radiotherapy (SBRT) is an external beam radiotherapy modality in which large radiation doses are delivered over five or fewer fractions. Two forms of brachytherapy -- permanent seed implant low dose rate brachytherapy (LDR-BT) and temporary interstitial implant high dose rate brachytherapy (HDR-BT) -- are also options.
Source: Radiotherapy and Oncology - Category: Radiology Authors: Tags: Original Article Source Type: research
Authors: Hussain T, Mattheis S, Lang S Abstract The incidence of human papillomavirus (HPV)-positive oropharyngeal carcinomas is increasing worldwide. Due to a markedly different response to treatment compared to HPV-negative oropharyngeal carcinomas, determining the ideal therapeutic approach can be challenging. Particularly in never-smokers, HPV-positive oropharyngeal carcinomas respond well to primary radiation therapy; at the same time recent studies indicate comparable survival after primary surgery. For stage I tumors according to TNM‑8, retrospective analyses show very good oncologic outcomes aft...
Source: HNO - Category: ENT & OMF Tags: HNO Source Type: research
CONCLUSIONS: QOL is largely preserved in brain metastasis patients treated with SRS. Higher RPA class, upfront whole-brain radiation therapy, and greater intracranial disease burden are independent predictors of post-SRS QOL deterioration. Worse pre-SRS QOL predicts shorter survival. Assessment of QOL is recommended in brain metastasis patients managed with SRS. PMID: 32650308 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - Category: Neurosurgery Authors: Tags: J Neurosurg Source Type: research
Our study shows the distribution patterns and prognoses of distant metastases among 4 histological types in NPC. A nomogram was constructed for clinical use based on 4 independent prognostic risk indicators, including histology, radiation therapy, chemotherapy and metastatic status. Our findings provide a reference for clinical decision ‐making and future diagnostic screening tests for NPC with distant metastases. AbstractCurrently, the features and prognosis of nasopharyngeal carcinoma (NPC) with distant metastases are still rarely reported. Thus, the main purpose of our study was to investigate the metastasis patterns ...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
CONCLUSIONS: In selected cases, MISS surgeries may be considered as a valid alternative to open surgery. Although the efficacy of PPSF has been well documented in trauma or degenerative spine surgery, there is not sufficient literature about MISS techniques in spinal metastasis and further studies are needed to elucidate the most appropriate patient in which this approach could represent the gold standard of treatment. PMID: 32633339 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Authors: Vasudevan HN, Yom SS Abstract The addition of chemotherapy to radiation therapy (RT) has been established for decades to improve outcomes in patients with head and neck cancer (HNC). Concurrent chemoradiation increases both local control and overall survival but at the cost of significant toxicity, motivating extensive investigations to optimize the balance of clinical efficacy and adverse effects. This review discusses the rationale and seminal studies underlying the concurrent chemoradiation treatment paradigm in HNC, and describes attempts to better tailor systemic therapy beyond standard-of-care cispla...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research
Since its early days in the late 1990s, cryopreservation of ovarian tissue (OTC) has developed from being an experimental procedure offered to a select few to being a standard method of fertility preservation that is particularly relevant for young girls and adolescents and women in need of urgent chemotherapy or radiation therapy in whom there is no time for controlled ovarian stimulation and egg harvesting. Although some countries and centers have been very active in developing and offering OTC to patients with cancer or other life-threatening diseases, others have been more reluctant, waiting for sufficient data to emer...
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Reflections Source Type: research
This article aims to provide an update on literature data related to mandibular osteoradionecrosis (MORN) secondary to the irradiation of the head and neck region.Recent FindingsRadiotherapy (RT) plays a crucial role in the contemporary management of head and neck cancer (HNC) patients and, despite intensity-modulated technique (IMRT), mandibular osteoradionecrosis (MORN) remains a significant RT-related complication. Based on its clinical manifestation, MORN can negatively affect patients ’ quality of life. Preventive interventions should be prioritized.SummaryThis manuscript is expected to represent an opportunity ...
Source: Current Oncology Reports - Category: Cancer & Oncology Source Type: research
Radiation therapy equipment developer RefleXion Medical and radiopharmaceutical...Read more on AuntMinnie.comRelated Reading: RefleXion to collaborate with Merck on clinical trial RefleXion raises $100M in equity round RefleXion sells first X1 rad therapy machine RefleXion gets FDA nod for rad therapy Meet the Minnies 2019 semifinal candidates
Source: Headlines - Category: Radiology Source Type: news
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