SBRT re-irradiation after prior SBRT in pancreatic cancer —outcomes and a focus on stomach and bowel toxicity
ConclusionSBRT after prior SBRT for pancreatic cancer is a reasonably safe and efficacious treatment that leads to durable local control and reasonable survival. Retreatment of the duodenum and stomach with a D0.03cc and D1cc of at least 40  Gy may be safe, although more data is needed. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - December 15, 2020 Category: Cancer & Oncology Source Type: research

Stereotactic body radiation therapy for early-stage non-small cell lung cancer in the USA: patterns of adoption and potential healthcare disparities
This study evaluated trends in SBRT utilization to identify potential disparities.MethodsThis was a cancer registry study using the National Cancer Database (NCDB). The NCDB was queried for patients diagnosed with early-stage NSCLC from 2004 to 2016. Patients receiving surgery, chemotherapy, radiation not meeting criteria for SBRT, or other ablative procedures were excluded. SBRT use in treatment facilities over time was evaluated, and patients were analyzed by various socioeconomic factors to determine predictors of SBRT vs no-treatment. Multivariate and Cox regression analyses were performed to determine the extent to wh...
Source: Journal of Radiation Oncology - December 2, 2020 Category: Cancer & Oncology Source Type: research

Indirect evaluation of pretreatment imaging protocols and their clinical impact on patient dose delivery in radiotherapy
ConclusionThis study plays a vital role in establishing optimum pretreatment imaging protocols in busy clinics. Three days a week imaging protocol is the best suit protocol found with minimal deviation and ample implementation feasibility. This study proposed an opinion pertaining to the revision of setup margin formula in order to accommodate variation due to imaging techniques and frequency of imaging attempted during radiotherapy. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - November 26, 2020 Category: Cancer & Oncology Source Type: research

Feasibility of simulation contrast-enhanced computed tomography (CECT Sim ) of the head and neck region to detect early nodal recurrence in postoperative oral squamous cell carcinoma in a resource-constrained setup
ConclusionCECTSim may be helpful in the detection of EPNR in OSCC and may preclude the need for additional imaging before the start of PORT. CECTSim may also facilitate the appropriate determination of the radiation volume and appropriate dose to the corresponding target volume. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - November 18, 2020 Category: Cancer & Oncology Source Type: research

Impact of lung tumor motion on dose delivered to organ at risk in lung stereotactic body radiation therapy
ConclusionThe dose received by the OARs depends on the amplitude of tumor motion and is relative to the OAR ’s location and motion, due to patient respiration and heart contribution. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - November 10, 2020 Category: Cancer & Oncology Source Type: research

Dosimetric evaluation of a rotating gamma-ray system for stereotactic body radiation therapy
ConclusionThe new CybeRay machine showed promising dosimetric capabilities for stereotactic radiosurgery and radiotherapy of extra- and intra-cranial lesions. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - October 21, 2020 Category: Cancer & Oncology Source Type: research

Efficacy of palliative SBRT in local control of sarcoma
ConclusionOur institutional experience provides encouraging evidence of the feasibility of SBRT in the palliation of sarcoma. Poor overall survival is a substantial competing risk in these patients. Further studies will be required to identify the ideal dose and fractionation across histological subtypes. Prospective clinical trials may be warranted. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - October 20, 2020 Category: Cancer & Oncology Source Type: research

Early detection of SARS-CoV-2 from staging PET-CT
ConclusionIn the COVID-19 era, oncologists obtaining routine staging imaging should have high diagnostic suspicion for subclinical SARS-CoV-2 infection. To avoid precipitating severe pneumonia and hospitalization, multidisciplinary discussion with risk-benefit analysis is recommended before initiating immunosuppressive therapies such as chemoradiation. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - September 28, 2020 Category: Cancer & Oncology Source Type: research

Dosimetric comparison of three-dimensional conformal radiotherapy and static and dynamic intensity-modulated radiotherapy for the treatment of early-stage glottic cancer
ConclusionThe D-IMRT and S-IMRT techniques allowed more homogeneous dose distributions in PTV. Considering the dose to OAR, S-IMRT was more appropriate rather than 3DCRT and D-IMRT. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - September 18, 2020 Category: Cancer & Oncology Source Type: research

A comparison of quality of life and acute toxicity in patients applied with Tomo-helical IMRT and conformal radiotherapy for breast cancer
ConclusionThe findings of RT toxicity and quality of life appear to be superior in patients applied with Tomo-helical IMRT compared with patients treated with 3D-CRT. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - August 30, 2020 Category: Cancer & Oncology Source Type: research

An observational study of post-operative volumetric modulated arc radiotherapy (VMAT) of breast cancer by immobilizing patients on All-in-One (AIO ™) solution breast and lung board without using thermoplastic mask: risk of collision of gantry with couch exists if acquisition of Cone Beam Computed Tomography (CBCT) is attempted for set-up verification
ConclusionPerforming CBCT for generating 3D images for computed tomography (CT) reconstruction may not be practical for patient set-up verification of post-operative radiotherapy of unilateral breast cancer patients positioned supine on breast and lung board. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - August 28, 2020 Category: Cancer & Oncology Source Type: research

Whole breast irradiation with high tangents in the prone position
ConclusionsThis series demonstrates the feasibility of high tangents in the prone position, offering good coverage of level I LN, particularly with
Source: Journal of Radiation Oncology - August 24, 2020 Category: Cancer & Oncology Source Type: research

Peer review program to enhance treatment planning quality assurance for community radiation oncologists
ConclusionA two-step QA program was considered highly valuable by all participants allowing easily implanted mechanisms for standardization, higher case volume, and shared educational resources for small academic satellite CROs who are faced with the challenge of caring for a diverse community cancer population. Feasibility suggests the model could serve as a model for other CRO. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - July 29, 2020 Category: Cancer & Oncology Source Type: research

Dosimetric comparison of linac-based modulated techniques for hippocampal sparing whole brain radiotherapy
ConclusionVMAT plans provide better target volume coverage, homogeneity, conformity, and hippocampus sparing when compared with IMRT plans. VMAT plans are also the best in terms of treatment efficiency since they require a much smaller number of MUs and thus a shorter treatment time than IMRT plans. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - July 6, 2020 Category: Cancer & Oncology Source Type: research

Brain metastases from small cell lung cancer: survival after whole brain radiotherapy versus stereotactic radiosurgery of recursive partitioning analysis class I –II patients
(Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - June 24, 2020 Category: Cancer & Oncology Source Type: research

Volumetric modulated craniospinal irradiation workflow optimization through quantitative analytics: a single-institution case study comparing pediatric and adult settings
AbstractObjectiveWe used quantitative analytics to assess the efficiency of the clinical workflow for radiation therapy delivery in children and adults focusing on our experience with volumetric modulated arc therapy (VMAT) craniospinal irradiation (CSI).MethodsWe retrospectively collected clinical and treatment specific data between June 2013 and November 2018 for 614 VMAT CSI sessions of 41 pediatric patients and 48 VMAT CSI sessions of 6 adult patients treated at two hospitals within the same academic institution. Descriptive statistics were generated and a multiple linear regression model was created to predict total r...
Source: Journal of Radiation Oncology - June 17, 2020 Category: Cancer & Oncology Source Type: research

Lymph node –directed simultaneous integrated boost in patients with clinically lymph node–positive cervical cancer treated with definitive chemoradiotherapy: clinical outcomes and toxicity
ConclusionChemoradiation with a LN-directed SIB for women with LN-positive cervical cancer is well tolerated and is associated with excellent oncologic outcomes.SummaryIn this report, we evaluated the oncologic efficacy and adverse events associated with definitive chemoradiotherapy with a simultaneous integrated boost to grossly involved lymph nodes for women with lymph node –positive cervical cancer. We have identified acceptable rates of adverse events and excellent oncologic outcomes, even in a very high risk cohort of women with cervical cancer. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - June 8, 2020 Category: Cancer & Oncology Source Type: research

Dosimetric correlations with urinary quality of life in patients receiving post-prostatectomy radiation therapy
ConclusionThere is an acute worsening of urinary symptoms among men receiving modern post-prostatectomy radiation. Worsening of urgency is associated with bladder dosimetry while flow, frequency, nocturia, and dysuria are not. This data can be used during treatment planning to reduce acute urinary toxicity during post-prostatectomy radiation. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - June 2, 2020 Category: Cancer & Oncology Source Type: research

Capturing 3D patient features for rapid prototyping in radiotherapy prior to simulation
ConclusionWe present a new workflow that combines current known methods of both rapidly scanning a patient ’s surface and the subsequent rapid creation of bolus that then increases bolus conformity, improves comfort and the patient experience, reduces simulation time, and may decrease exposure to radiation. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - May 29, 2020 Category: Cancer & Oncology Source Type: research

Radiofrequency radiation: carcinogenic and other potential risks
In conclusion, there is neither convincing evidence nor theoretic plausibility of a cause-effect relationship between RFR and cancer. Reliable evidence can be obtained by large-scale animal experiments. To make experiments less expensive, it would suffice to maintain large animal groups in equal conditions and to record the life span. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - May 24, 2020 Category: Cancer & Oncology Source Type: research

Biologic subtypes as a predictor of local control in patients with brain metastases from breast cancer after stereotactic radiosurgery
ConclusionThis study shows that in BC patients with BM treated with SRS, biologic subtype affects LC. Consideration of radiation treatment intensification or altered fractionation to improve LC may be indicated for the TN subtype. Further multicenter studies are necessary to corroborate our results. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - May 23, 2020 Category: Cancer & Oncology Source Type: research

Recommendations for radiosurgery and stereotactic ablative radiotherapy terminology to guide clinical and research practices for the medical oncologist, radiation oncologist, and surgeon
(Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - May 14, 2020 Category: Cancer & Oncology Source Type: research

A single-institution study of intraoperative radiation therapy (IORT) using electronic brachytherapy
AbstractObjectiveTwo prospective randomized trials, TARGIT-A and ELIOT, have shown intraoperative radiation (IORT) to be safe and well-tolerated in low-risk patients. Electronic IORT with the Xoft Axxent system has few long-term reported results.Materials/methodsA total of 100 patients (101 tumors) were treated with partial mastectomy and intraoperative brachytherapy. Electronic brachytherapy via IORT was utilized to deliver 20  Gy to the balloon surface in a single fraction prior to completion of surgery. Necessity of additional intervention with surgery or radiation was noted, as was the presence of clinical seroma ...
Source: Journal of Radiation Oncology - May 10, 2020 Category: Cancer & Oncology Source Type: research

Radiotherapy for maxillary sinus carcinoma: dosimetric comparison of volumetric modulated arc therapy with 0 ° and 90° collimator intensity modulated radiation therapy
ConclusionsThe VMAT has better CI of target volume and could have better OARs sparing effects for optic chiasm, ipsilateral lens and ipsilateral optic nerve compared with IMRT for MSCs. The VMAT also could use fewer MUs and has lower treatment delivery times. The nc-IMRT could have better ipsilateral lens sparing and use fewer MUs compared with zc-IMRT. Therefore we could protect the ipsilateral lens better through changing the angle of the collimator from 0 ° to 90° when the IMRT technique is used for the treatment of MSCs. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - May 9, 2020 Category: Cancer & Oncology Source Type: research

Safety of nivolumab in combination with prior or concurrent radiation therapy in hepatocellular carcinoma
ConclusionCombination RT and nivolumab is generally safe in the management of unresectable HCC with a low rate of serious adverse events. Prospective trials investigating the efficacy of combination nivolumab and RT are warranted. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - May 8, 2020 Category: Cancer & Oncology Source Type: research

Comparison of ICRU 38 rectal reference point dose estimates with measured dose in vivo in cobalt-60 HDR brachytherapy for cervical cancer
The objective of this study was to compare the ICRU 38 calculated rectal dose with in vivo dosimetry measured doses in cobalt-60 HDR brachytherapy for cervical cancer.MethodsA total of 48 brachytherapy insertions done on 15 patients treated from January to March 2017 at our institution were included in this prospective cross-sectional study.ResultsThe results demonstrated no significant difference between the computed ICRU rectal point dose and in vivo maximum measured rectal dose ((r) 0.6208,p 
Source: Journal of Radiation Oncology - May 7, 2020 Category: Cancer & Oncology Source Type: research

Analysis of setup uncertainties and determine the variation of the clinical target volume (CTV) to planning target volume (PTV) margin for various tumor sites treated with three-dimensional IGRT couch using KV-CBCT
ConclusionsFor adequate target coverage, van Herk-calculated CTV to PTV margin are used in our institution. To reduce the setup uncertainties and CTV to PTV margin frequently, CBCT is essential. In the yearly comparison of CTV to PTV margin, we observed that for brain and H&N cases were not in descending order due to the differently deformation of head rests which were used for molding and treatment separately. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - May 5, 2020 Category: Cancer & Oncology Source Type: research

Perioperative high-dose-rate brachytherapy (PoHDR) in the multidisciplinary management of adult soft tissue sarcomas: a realistic alternative for a moderate radiotherapy dose escalation
ConclusionsHDR PoBT is safe, feasible, and well tolerated and allows for a moderate radiation dose escalation with acceptable rates of tumor control. Further follow-up is necessary to confirm impact on final outcomes. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - May 5, 2020 Category: Cancer & Oncology Source Type: research

Long-term outcomes of hypofractionated stereotactic radiotherapy for refractory functional pituitary adenoma
ConclusionHSRT for refractory pituitary adenoma is well-tolerated with long-term local and biochemical control comparable with single-fraction SRS or IMRT. Prospective studies should evaluate whether HSRT provides non-inferior biochemical control and improved toxicity compared with single-fraction SRS. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - May 2, 2020 Category: Cancer & Oncology Source Type: research

Clinical outcomes and toxicity of proton radiotherapy for vestibular schwannomas: a systematic review
AbstractObjectiveIntensity-modulated radiation therapy (IMRT) using a volumetric-modulated arc therapy technique may offer dosimetric and clinical benefits compared to the historical standard of care 3D conformal radiotherapy (3D-CRT) in definitive treatment of bladder cancer. We hypothesized that IMRT with CBCT would reduce dose to the rectum, bowel, and bladder compared to 3D-CRT.MethodsWe reviewed nineteen patients treated with maximal transurethral resection of bladder tumor followed by concurrent chemotherapy with IMRT. All patients received 45  Gy to the entire empty bladder followed by 19.8 Gy tumor boost ...
Source: Journal of Radiation Oncology - February 16, 2020 Category: Cancer & Oncology Source Type: research

The utilization patterns and comparative effectiveness of systemic therapy with high-dose thoracic radiotherapy or low-dose thoracic radiotherapy versus systemic therapy alone in newly diagnosed metastatic non-small cell lung cancer patients
AbstractPurposeWe used the National Cancer Database (NCDB) to investigate the utilization and effectiveness of high-dose thoracic radiotherapy (RT) with systemic therapy (ST), compared to low-dose RT with ST, or ST alone in patients with metastatic non-small cell lung cancer (mNSCLC), hypothesizing that the use of high-dose thoracic RT with ST would increase in time and be associated with improved overall survival (OS).Materials and methodsWe identified mNSCLC patients diagnosed between 2004 and 2014 whose initial treatment comprised ST and thoracic RT (ST-RT;n = 46,315) or ST and no thoracic or extrathoracic...
Source: Journal of Radiation Oncology - February 10, 2020 Category: Cancer & Oncology Source Type: research

The value of prostate-specific antigen monitoring during salvage radiotherapy: a retrospective study and systematic review with meta-analysis
ConclusionThese results need confirmation using prospective data before being applied to clinical practice and could help physician to choose the correct therapeutic strategy. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - January 28, 2020 Category: Cancer & Oncology Source Type: research

Outcome of surgery and radiotherapy for dermatofibrosarcoma protuberans: 5-year experience from two tertiary centers of eastern India
ConclusionCombined modality therapy with surgery and radiotherapy for cases of close or inadequate margin results in good local control with acceptable toxicity, in cases where re-surgery is not possible or not contemplated. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - January 16, 2020 Category: Cancer & Oncology Source Type: research

Intensity-modulated radiotherapy is superior to three-dimensional conformal radiotherapy in the trimodality management of muscle-invasive bladder cancer with daily cone beam computed tomography optimization
AbstractObjectiveIntensity-modulated radiation therapy (IMRT) using a volumetric-modulated arc therapy technique may offer dosimetric and clinical benefits compared to the historical standard of care 3D conformal radiotherapy (3D-CRT) in definitive treatment of bladder cancer. We hypothesized that IMRT with CBCT would reduce dose to the rectum, bowel, and bladder compared to 3D-CRT.MethodsWe reviewed nineteen patients treated with maximal transurethral resection of bladder tumor followed by concurrent chemotherapy with IMRT. All patients received 45  Gy to the entire empty bladder followed by 19.8 Gy tumor boost ...
Source: Journal of Radiation Oncology - December 17, 2019 Category: Cancer & Oncology Source Type: research

Complications and toxicity of re-irradiation following total laryngectomy for laryngeal cancer
ConclusionPatients undergoing re-irradiation for recurrent laryngeal cancer have a poor prognosis with high risk of progression or recurrence. Re-irradiation may offer survival benefit at the expense of significant toxicities. The incidence of severe toxicity is high enough to warrant pretreatment counseling. Carotid blowout was seen in 15% of patients unrelated to cancer progression. Caution should be exercised in re-irradiated patients before instrumentation of the aerodigestive tract. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - December 12, 2019 Category: Cancer & Oncology Source Type: research

Temporalis muscle width as a measure of sarcopenia correlates with overall survival in patients with newly diagnosed glioblastoma
ConclusionOur results suggest sarcopenia and TMW correlate with GBM OS. Prospective validation of sarcopenia is needed to evaluate its potential in determining optimal patient treatment. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - December 12, 2019 Category: Cancer & Oncology Source Type: research

Delays in radiation therapy as a result of insurance peer-to-peer prior authorizations among lung cancer patients
AbstractObjectivesLung cancer is the leading cause of cancer death in the USA and timely treatment plays a major role in the prognosis. Peer-to-peer insurance prior authorizations are believed to represent a major cause of treatment delays. However, the effect of peer-to-peer prior authorizations on radiotherapy treatment delays in lung cancer remains unknown.MethodsWe reviewed departmental treatment records between September 2015 and 2018 for patients who received radiation therapy (RT) with curative intent for lung cancer. Our primary endpoint was delay in RT initiation; delay in RT simulation served as a secondary endpo...
Source: Journal of Radiation Oncology - December 9, 2019 Category: Cancer & Oncology Source Type: research

Patterns of relapse in older women diagnosed with estrogen receptor (ER) –positive early-stage breast cancer (BC) treated with lumpectomy without adjuvant endocrine therapy (ET)
ConclusionPatterns of relapse in older women with ER-positive early-stage BC note that local relapse is the most common site of failure. In this study, we also observed a low risk of distant relapse among patients not receiving ET. These observations on relapse patterns suggest that older women with early-stage BC may derive more benefit from adjuvant RT alone and be spared the potential side effects of ET. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - November 17, 2019 Category: Cancer & Oncology Source Type: research

Long-term clinical outcomes of 538 prostate carcinoma patients treated with combination high-dose-rate brachytherapy and external beam radiotherapy
ConclusionCombined HDR-B/EBRT for the treatment of clinically localized prostate cancer provides superb clinical outcomes with excellent 5-year bRFS, dMFS, OS, and late GI/GU toxicity rates. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - November 8, 2019 Category: Cancer & Oncology Source Type: research

Definitive chemoradiation followed by stereotactic body radiotherapy boost for inoperable endometrial cancer
ConclusionDefinitive chemoradiation with SBRT boost is safe and effective alternative when BB is not possible. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - October 24, 2019 Category: Cancer & Oncology Source Type: research

Dosimetric evaluation of the dose calculation accuracy of different algorithms for two different treatment techniques during whole breast irradiation
ConclusionWhen using the Eclipse TPS for breast cancer, AXB should be used instead of the AAA algorithm, bearing in mind that the AXB may still overestimate all OARs doses. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - October 22, 2019 Category: Cancer & Oncology Source Type: research

Thoracic radiotherapy for extensive-stage small-cell lung cancer: what is the optimal dose and timing?
AbstractSmall-cell lung cancer (SCLC) is a neuroendocrine tumor that represents about 12 –20% of all lung cancers. Most of the SCLC patients present with extensive-stage (ES) disease. Primary therapy for ES-SCLC is 4–6 cycles of platinum-based chemotherapy (CT) followed by prophylactic cranial irradiation (PCI) in selected cases. Although the response rate to CT is approximately 60– 70%, median survival times are very limited. The main problem of ES-SCLC patients after CT is intra-thoracic tumor recurrence since 75% of the patients had persisting intra-thoracic disease after CT, and approximately 90% of t...
Source: Journal of Radiation Oncology - October 22, 2019 Category: Cancer & Oncology Source Type: research

Therapeutic value of postmastectomy radiation therapy for T1 –2 breast cancer with 1–3 positive lymph nodes
ConclusionsPMRT tended to improve LRR and disease-free survival. The omission of PMRT is carefully determined. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - October 15, 2019 Category: Cancer & Oncology Source Type: research

Evaluating improvements in cardiac dosimetry in breast radiotherapy and comparison of cardiac sparing techniques
AbstractPurpose/objective(s)Data from Darby et al. demonstrated that cardiac dose in patients undergoing breast radiation therapy is associated with cardiac events. Cardiac dose is primarily dependent on treatment laterality and treatment fields. More recently, techniques such deep inspiratory breath hold (DIBH) and prone positioning have been used as cardiac sparing techniques. The purpose of this study is to assess changes in cardiac dosimetry with cardiac sparing techniques.Materials/methodsThis retrospective study included breast cancer patients treated from 2010 to 2018 at a single institution. Mean heart dose (MHD) w...
Source: Journal of Radiation Oncology - October 10, 2019 Category: Cancer & Oncology Source Type: research

Impact of choice of dose calculation algorithm on PTV and OAR doses in lung SBRT
ConclusionKnowing the strengths and limitations of clinical treatment planning system allows more consistent and accurate dose comparison for patients enrolled in protocol studies. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - August 29, 2019 Category: Cancer & Oncology Source Type: research

Patterns of utilization and comparative efficacy of altered fractionation and concurrent chemoradiation for treatment for T2N0M0 glottic carcinoma
AbstractObjectivesTo study radiotherapeutic treatment approaches in larynx-preservation for T2N0M0 glottic carcinoma at free-standing centers in the USA.MethodsWe retrospectively audited fractionation and chemoradiation at 59 centers in 5 geographic regions from 2000 to 2015. Chi-squared test and Fisher ’s exact test were used to compare frequencies, the Cox proportional hazards model and Kaplan-Meier procedure were used for survival analyses, and log-rank test to compare survival curves.ResultsAmong 180 patients, chemoradiation, accelerated hypofractionation (2.25  Gy/fraction), and hyperfractionation was given...
Source: Journal of Radiation Oncology - August 11, 2019 Category: Cancer & Oncology Source Type: research

Assessment of the alpha/beta ratio of the optic pathway to adjust hypofractionated stereotactic radiosurgery regimens for perioptic lesions
ConclusionCompared to single-fraction SRS, a significant intrinsic benefit from hypofractionation can be achieved, not only for perioptic malignant tumors, but for benign lesions as well, because of the very low alpha/beta ratio of the optic system of 1.03  Gy. An increased single fraction equivalent dose of up to 10% for perioptic meningiomas and of more than 25% for malignant tumors can be reached with optimized hypofractionated stereotactic radiosurgery schedules. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - August 9, 2019 Category: Cancer & Oncology Source Type: research

Letter to the Editor concerning “Re-irradiation in gynaecological cancers, present experiences and future hopes”
(Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - July 9, 2019 Category: Cancer & Oncology Source Type: research

Challenges in the re-irradiation of locally advanced head and neck cancers: outcomes and toxicities
ConclusionRe-irradiation with IMRT for locally advanced HN recurrences either definitively or after salvage surgery is feasible, but treatment-related toxicity remains significant. Patients who received surgery as a component of their initial treatment and those with more advanced stage disease may be more difficult to salvage with re-irradiation. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - July 8, 2019 Category: Cancer & Oncology Source Type: research

Stereotactic body radiotherapy versus conventional radiotherapy for early-stage small cell lung cancer
This study was designed to compare survival outcomes for non-surgically managed T1-T2N0M0 small cell lung cancer (SCLC) patients who received either stereotactic body radiation therapy (SBRT) or conventionally fractionated radiotherapy (CFRT) using the National Cancer Database (NCDB).MethodsThe NCDB was queried between 2004 and 2015 for patients with T1-T2N0M0 SCLC. Patients must have been treated with curative intent SBRT or CFRT (delivered daily or twice daily, 45 –70 Gy) with or without chemotherapy. The primary outcome was overall survival (OS). A subset analysis of patients receiving chemotherapy was also p...
Source: Journal of Radiation Oncology - July 3, 2019 Category: Cancer & Oncology Source Type: research