Dosimetric correlations with urinary quality of life in patients receiving post-prostatectomy radiation therapy
ConclusionThere is an acute worsening of urinary symptoms among men receiving modern post-prostatectomy radiation. Worsening of urgency is associated with bladder dosimetry while flow, frequency, nocturia, and dysuria are not. This data can be used during treatment planning to reduce acute urinary toxicity during post-prostatectomy radiation. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - June 3, 2020 Category: Cancer & Oncology Source Type: research

Capturing 3D patient features for rapid prototyping in radiotherapy prior to simulation
ConclusionWe present a new workflow that combines current known methods of both rapidly scanning a patient ’s surface and the subsequent rapid creation of bolus that then increases bolus conformity, improves comfort and the patient experience, reduces simulation time, and may decrease exposure to radiation. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - May 30, 2020 Category: Cancer & Oncology Source Type: research

Radiofrequency radiation: carcinogenic and other potential risks
In conclusion, there is neither convincing evidence nor theoretic plausibility of a cause-effect relationship between RFR and cancer. Reliable evidence can be obtained by large-scale animal experiments. To make experiments less expensive, it would suffice to maintain large animal groups in equal conditions and to record the life span. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - May 25, 2020 Category: Cancer & Oncology Source Type: research

Biologic subtypes as a predictor of local control in patients with brain metastases from breast cancer after stereotactic radiosurgery
ConclusionThis study shows that in BC patients with BM treated with SRS, biologic subtype affects LC. Consideration of radiation treatment intensification or altered fractionation to improve LC may be indicated for the TN subtype. Further multicenter studies are necessary to corroborate our results. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - May 24, 2020 Category: Cancer & Oncology Source Type: research

Recommendations for radiosurgery and stereotactic ablative radiotherapy terminology to guide clinical and research practices for the medical oncologist, radiation oncologist, and surgeon
(Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - May 15, 2020 Category: Cancer & Oncology Source Type: research

A single-institution study of intraoperative radiation therapy (IORT) using electronic brachytherapy
AbstractObjectiveTwo prospective randomized trials, TARGIT-A and ELIOT, have shown intraoperative radiation (IORT) to be safe and well-tolerated in low-risk patients. Electronic IORT with the Xoft Axxent system has few long-term reported results.Materials/methodsA total of 100 patients (101 tumors) were treated with partial mastectomy and intraoperative brachytherapy. Electronic brachytherapy via IORT was utilized to deliver 20  Gy to the balloon surface in a single fraction prior to completion of surgery. Necessity of additional intervention with surgery or radiation was noted, as was the presence of clinical seroma ...
Source: Journal of Radiation Oncology - May 11, 2020 Category: Cancer & Oncology Source Type: research

Radiotherapy for maxillary sinus carcinoma: dosimetric comparison of volumetric modulated arc therapy with 0 ° and 90° collimator intensity modulated radiation therapy
ConclusionsThe VMAT has better CI of target volume and could have better OARs sparing effects for optic chiasm, ipsilateral lens and ipsilateral optic nerve compared with IMRT for MSCs. The VMAT also could use fewer MUs and has lower treatment delivery times. The nc-IMRT could have better ipsilateral lens sparing and use fewer MUs compared with zc-IMRT. Therefore we could protect the ipsilateral lens better through changing the angle of the collimator from 0 ° to 90° when the IMRT technique is used for the treatment of MSCs. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - May 10, 2020 Category: Cancer & Oncology Source Type: research

Safety of nivolumab in combination with prior or concurrent radiation therapy in hepatocellular carcinoma
ConclusionCombination RT and nivolumab is generally safe in the management of unresectable HCC with a low rate of serious adverse events. Prospective trials investigating the efficacy of combination nivolumab and RT are warranted. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - May 9, 2020 Category: Cancer & Oncology Source Type: research

Comparison of ICRU 38 rectal reference point dose estimates with measured dose in vivo in cobalt-60 HDR brachytherapy for cervical cancer
The objective of this study was to compare the ICRU 38 calculated rectal dose with in vivo dosimetry measured doses in cobalt-60 HDR brachytherapy for cervical cancer.MethodsA total of 48 brachytherapy insertions done on 15 patients treated from January to March 2017 at our institution were included in this prospective cross-sectional study.ResultsThe results demonstrated no significant difference between the computed ICRU rectal point dose and in vivo maximum measured rectal dose ((r) 0.6208,p 
Source: Journal of Radiation Oncology - May 8, 2020 Category: Cancer & Oncology Source Type: research

Analysis of setup uncertainties and determine the variation of the clinical target volume (CTV) to planning target volume (PTV) margin for various tumor sites treated with three-dimensional IGRT couch using KV-CBCT
ConclusionsFor adequate target coverage, van Herk-calculated CTV to PTV margin are used in our institution. To reduce the setup uncertainties and CTV to PTV margin frequently, CBCT is essential. In the yearly comparison of CTV to PTV margin, we observed that for brain and H&N cases were not in descending order due to the differently deformation of head rests which were used for molding and treatment separately. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - May 6, 2020 Category: Cancer & Oncology Source Type: research

Perioperative high-dose-rate brachytherapy (PoHDR) in the multidisciplinary management of adult soft tissue sarcomas: a realistic alternative for a moderate radiotherapy dose escalation
ConclusionsHDR PoBT is safe, feasible, and well tolerated and allows for a moderate radiation dose escalation with acceptable rates of tumor control. Further follow-up is necessary to confirm impact on final outcomes. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - May 6, 2020 Category: Cancer & Oncology Source Type: research

Long-term outcomes of hypofractionated stereotactic radiotherapy for refractory functional pituitary adenoma
ConclusionHSRT for refractory pituitary adenoma is well-tolerated with long-term local and biochemical control comparable with single-fraction SRS or IMRT. Prospective studies should evaluate whether HSRT provides non-inferior biochemical control and improved toxicity compared with single-fraction SRS. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - May 3, 2020 Category: Cancer & Oncology Source Type: research

Clinical outcomes and toxicity of proton radiotherapy for vestibular schwannomas: a systematic review
AbstractObjectiveIntensity-modulated radiation therapy (IMRT) using a volumetric-modulated arc therapy technique may offer dosimetric and clinical benefits compared to the historical standard of care 3D conformal radiotherapy (3D-CRT) in definitive treatment of bladder cancer. We hypothesized that IMRT with CBCT would reduce dose to the rectum, bowel, and bladder compared to 3D-CRT.MethodsWe reviewed nineteen patients treated with maximal transurethral resection of bladder tumor followed by concurrent chemotherapy with IMRT. All patients received 45  Gy to the entire empty bladder followed by 19.8 Gy tumor boost ...
Source: Journal of Radiation Oncology - February 17, 2020 Category: Cancer & Oncology Source Type: research

The utilization patterns and comparative effectiveness of systemic therapy with high-dose thoracic radiotherapy or low-dose thoracic radiotherapy versus systemic therapy alone in newly diagnosed metastatic non-small cell lung cancer patients
AbstractPurposeWe used the National Cancer Database (NCDB) to investigate the utilization and effectiveness of high-dose thoracic radiotherapy (RT) with systemic therapy (ST), compared to low-dose RT with ST, or ST alone in patients with metastatic non-small cell lung cancer (mNSCLC), hypothesizing that the use of high-dose thoracic RT with ST would increase in time and be associated with improved overall survival (OS).Materials and methodsWe identified mNSCLC patients diagnosed between 2004 and 2014 whose initial treatment comprised ST and thoracic RT (ST-RT;n = 46,315) or ST and no thoracic or extrathoracic...
Source: Journal of Radiation Oncology - February 11, 2020 Category: Cancer & Oncology Source Type: research

The value of prostate-specific antigen monitoring during salvage radiotherapy: a retrospective study and systematic review with meta-analysis
ConclusionThese results need confirmation using prospective data before being applied to clinical practice and could help physician to choose the correct therapeutic strategy. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - January 29, 2020 Category: Cancer & Oncology Source Type: research

Outcome of surgery and radiotherapy for dermatofibrosarcoma protuberans: 5-year experience from two tertiary centers of eastern India
ConclusionCombined modality therapy with surgery and radiotherapy for cases of close or inadequate margin results in good local control with acceptable toxicity, in cases where re-surgery is not possible or not contemplated. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - January 17, 2020 Category: Cancer & Oncology Source Type: research

Intensity-modulated radiotherapy is superior to three-dimensional conformal radiotherapy in the trimodality management of muscle-invasive bladder cancer with daily cone beam computed tomography optimization
AbstractObjectiveIntensity-modulated radiation therapy (IMRT) using a volumetric-modulated arc therapy technique may offer dosimetric and clinical benefits compared to the historical standard of care 3D conformal radiotherapy (3D-CRT) in definitive treatment of bladder cancer. We hypothesized that IMRT with CBCT would reduce dose to the rectum, bowel, and bladder compared to 3D-CRT.MethodsWe reviewed nineteen patients treated with maximal transurethral resection of bladder tumor followed by concurrent chemotherapy with IMRT. All patients received 45  Gy to the entire empty bladder followed by 19.8 Gy tumor boost ...
Source: Journal of Radiation Oncology - December 18, 2019 Category: Cancer & Oncology Source Type: research

Complications and toxicity of re-irradiation following total laryngectomy for laryngeal cancer
ConclusionPatients undergoing re-irradiation for recurrent laryngeal cancer have a poor prognosis with high risk of progression or recurrence. Re-irradiation may offer survival benefit at the expense of significant toxicities. The incidence of severe toxicity is high enough to warrant pretreatment counseling. Carotid blowout was seen in 15% of patients unrelated to cancer progression. Caution should be exercised in re-irradiated patients before instrumentation of the aerodigestive tract. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - December 13, 2019 Category: Cancer & Oncology Source Type: research

Temporalis muscle width as a measure of sarcopenia correlates with overall survival in patients with newly diagnosed glioblastoma
ConclusionOur results suggest sarcopenia and TMW correlate with GBM OS. Prospective validation of sarcopenia is needed to evaluate its potential in determining optimal patient treatment. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - December 13, 2019 Category: Cancer & Oncology Source Type: research

Delays in radiation therapy as a result of insurance peer-to-peer prior authorizations among lung cancer patients
AbstractObjectivesLung cancer is the leading cause of cancer death in the USA and timely treatment plays a major role in the prognosis. Peer-to-peer insurance prior authorizations are believed to represent a major cause of treatment delays. However, the effect of peer-to-peer prior authorizations on radiotherapy treatment delays in lung cancer remains unknown.MethodsWe reviewed departmental treatment records between September 2015 and 2018 for patients who received radiation therapy (RT) with curative intent for lung cancer. Our primary endpoint was delay in RT initiation; delay in RT simulation served as a secondary endpo...
Source: Journal of Radiation Oncology - December 10, 2019 Category: Cancer & Oncology Source Type: research

Patterns of relapse in older women diagnosed with estrogen receptor (ER) –positive early-stage breast cancer (BC) treated with lumpectomy without adjuvant endocrine therapy (ET)
ConclusionPatterns of relapse in older women with ER-positive early-stage BC note that local relapse is the most common site of failure. In this study, we also observed a low risk of distant relapse among patients not receiving ET. These observations on relapse patterns suggest that older women with early-stage BC may derive more benefit from adjuvant RT alone and be spared the potential side effects of ET. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - November 18, 2019 Category: Cancer & Oncology Source Type: research

Long-term clinical outcomes of 538 prostate carcinoma patients treated with combination high-dose-rate brachytherapy and external beam radiotherapy
ConclusionCombined HDR-B/EBRT for the treatment of clinically localized prostate cancer provides superb clinical outcomes with excellent 5-year bRFS, dMFS, OS, and late GI/GU toxicity rates. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - November 9, 2019 Category: Cancer & Oncology Source Type: research

Definitive chemoradiation followed by stereotactic body radiotherapy boost for inoperable endometrial cancer
ConclusionDefinitive chemoradiation with SBRT boost is safe and effective alternative when BB is not possible. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - October 25, 2019 Category: Cancer & Oncology Source Type: research

Dosimetric evaluation of the dose calculation accuracy of different algorithms for two different treatment techniques during whole breast irradiation
ConclusionWhen using the Eclipse TPS for breast cancer, AXB should be used instead of the AAA algorithm, bearing in mind that the AXB may still overestimate all OARs doses. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - October 23, 2019 Category: Cancer & Oncology Source Type: research

Thoracic radiotherapy for extensive-stage small-cell lung cancer: what is the optimal dose and timing?
AbstractSmall-cell lung cancer (SCLC) is a neuroendocrine tumor that represents about 12 –20% of all lung cancers. Most of the SCLC patients present with extensive-stage (ES) disease. Primary therapy for ES-SCLC is 4–6 cycles of platinum-based chemotherapy (CT) followed by prophylactic cranial irradiation (PCI) in selected cases. Although the response rate to CT is approximately 60– 70%, median survival times are very limited. The main problem of ES-SCLC patients after CT is intra-thoracic tumor recurrence since 75% of the patients had persisting intra-thoracic disease after CT, and approximately 90% of t...
Source: Journal of Radiation Oncology - October 23, 2019 Category: Cancer & Oncology Source Type: research

Therapeutic value of postmastectomy radiation therapy for T1 –2 breast cancer with 1–3 positive lymph nodes
ConclusionsPMRT tended to improve LRR and disease-free survival. The omission of PMRT is carefully determined. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - October 16, 2019 Category: Cancer & Oncology Source Type: research

Evaluating improvements in cardiac dosimetry in breast radiotherapy and comparison of cardiac sparing techniques
AbstractPurpose/objective(s)Data from Darby et al. demonstrated that cardiac dose in patients undergoing breast radiation therapy is associated with cardiac events. Cardiac dose is primarily dependent on treatment laterality and treatment fields. More recently, techniques such deep inspiratory breath hold (DIBH) and prone positioning have been used as cardiac sparing techniques. The purpose of this study is to assess changes in cardiac dosimetry with cardiac sparing techniques.Materials/methodsThis retrospective study included breast cancer patients treated from 2010 to 2018 at a single institution. Mean heart dose (MHD) w...
Source: Journal of Radiation Oncology - October 11, 2019 Category: Cancer & Oncology Source Type: research

Impact of choice of dose calculation algorithm on PTV and OAR doses in lung SBRT
ConclusionKnowing the strengths and limitations of clinical treatment planning system allows more consistent and accurate dose comparison for patients enrolled in protocol studies. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - August 30, 2019 Category: Cancer & Oncology Source Type: research

Patterns of utilization and comparative efficacy of altered fractionation and concurrent chemoradiation for treatment for T2N0M0 glottic carcinoma
AbstractObjectivesTo study radiotherapeutic treatment approaches in larynx-preservation for T2N0M0 glottic carcinoma at free-standing centers in the USA.MethodsWe retrospectively audited fractionation and chemoradiation at 59 centers in 5 geographic regions from 2000 to 2015. Chi-squared test and Fisher ’s exact test were used to compare frequencies, the Cox proportional hazards model and Kaplan-Meier procedure were used for survival analyses, and log-rank test to compare survival curves.ResultsAmong 180 patients, chemoradiation, accelerated hypofractionation (2.25  Gy/fraction), and hyperfractionation was given...
Source: Journal of Radiation Oncology - August 12, 2019 Category: Cancer & Oncology Source Type: research

Assessment of the alpha/beta ratio of the optic pathway to adjust hypofractionated stereotactic radiosurgery regimens for perioptic lesions
ConclusionCompared to single-fraction SRS, a significant intrinsic benefit from hypofractionation can be achieved, not only for perioptic malignant tumors, but for benign lesions as well, because of the very low alpha/beta ratio of the optic system of 1.03  Gy. An increased single fraction equivalent dose of up to 10% for perioptic meningiomas and of more than 25% for malignant tumors can be reached with optimized hypofractionated stereotactic radiosurgery schedules. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - August 10, 2019 Category: Cancer & Oncology Source Type: research

Letter to the Editor concerning “Re-irradiation in gynaecological cancers, present experiences and future hopes”
(Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - July 10, 2019 Category: Cancer & Oncology Source Type: research

Challenges in the re-irradiation of locally advanced head and neck cancers: outcomes and toxicities
ConclusionRe-irradiation with IMRT for locally advanced HN recurrences either definitively or after salvage surgery is feasible, but treatment-related toxicity remains significant. Patients who received surgery as a component of their initial treatment and those with more advanced stage disease may be more difficult to salvage with re-irradiation. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - July 9, 2019 Category: Cancer & Oncology Source Type: research

Stereotactic body radiotherapy versus conventional radiotherapy for early-stage small cell lung cancer
This study was designed to compare survival outcomes for non-surgically managed T1-T2N0M0 small cell lung cancer (SCLC) patients who received either stereotactic body radiation therapy (SBRT) or conventionally fractionated radiotherapy (CFRT) using the National Cancer Database (NCDB).MethodsThe NCDB was queried between 2004 and 2015 for patients with T1-T2N0M0 SCLC. Patients must have been treated with curative intent SBRT or CFRT (delivered daily or twice daily, 45 –70 Gy) with or without chemotherapy. The primary outcome was overall survival (OS). A subset analysis of patients receiving chemotherapy was also p...
Source: Journal of Radiation Oncology - July 4, 2019 Category: Cancer & Oncology Source Type: research

Quantitative assessment of the efficacy of two different treatment plan optimization algorithms in treating tumors in locations of high heterogeneity
ConclusionsThe analysis for the lung, liver, and H&N cases indicated that both planning systems are equivocal for the majority of parameters measured, with a few differentiating trends. In H&N plans, Pinnacle showed improved parotid sparing but inferior performance in calculated GI values. Liver plans showed superiority of Raystation in GI computations, but the most notable differences were in the lung plans where Pinnacle spared the spinal cord significantly more in contrast to Raystation ’s performance but also delivered significantly more dose to the esophagus. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - July 3, 2019 Category: Cancer & Oncology Source Type: research

Salvage radiation therapy following radical prostatectomy in Stockholm County in 2008 –2016
ConclusionsPatients who started SRT at PSA  
Source: Journal of Radiation Oncology - June 22, 2019 Category: Cancer & Oncology Source Type: research

The systemic immunostimulatory effects of radiation therapy producing overall tumor control through the abscopal effect
ConclusionTogether, the clinical outcomes from published reports suggest that localized radiation therapy is capable of inducing abscopal effects in a wide variety of malignant tumors. With the advent of novel immunotherapies, the potential for immune activation by radiation defines a novel role for radiation therapy in the treatment of systemic disease. A clinical consideration of the abscopal effects produced by radiation therapy could lead to a revolutionary change in the current management of patients including radiation treatment strategies and immunotherapies for various malignant tumors. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - June 19, 2019 Category: Cancer & Oncology Source Type: research

The proceedings of the radiation oncology summit: acro 2019
(Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - June 13, 2019 Category: Cancer & Oncology Source Type: research

Neoadjuvant chemotherapy and high-dose radiation using intensity-modulated radiotherapy followed by rectal sparing TEM for distal rectal cancer
ConclusionsHigh-dose IMRT and chemotherapy followed by FTLE to treat distal rectal cancers are well tolerated and effective. FTLE may improve outcomes and minimize complications in appropriately selected patients. Randomized clinical trials are needed to compare it with standard surgery. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - May 30, 2019 Category: Cancer & Oncology Source Type: research

A risk model for lung complication combining radiation therapy and chronic obstructive pulmonary disease
AbstractPurposeTo develop a multi-variate risk model of lung complication for the treatment of locally advanced lung cancer combining radiation dosimetry and patient-specific risk factors including chronic obstructive pulmonary disease (COPD).Materials/methodsA retrospective study of 89 advanced lung cancer patients including clinical variables and radiation dose-volume metrics was correlated to overall survival (OS), local progression-free survival (LPFS), and lung complications. Lung toxicities were defined as grade 2 or higher lung complication including persistent cough requiring narcotic or antitussive agents, and dys...
Source: Journal of Radiation Oncology - May 28, 2019 Category: Cancer & Oncology Source Type: research

Effect of intermittent low-dose irradiation on the radiotherapy efficiency for MDA-MB-231 human breast adenocarcinoma cell line
AbstractIntroductionDespite the fact that high-dose radiotherapy is a main therapeutic modality in cancer treatment, recent evidence suggests that it might confer radioresistance. Hyper-radiosensitivity (HRS) is one of the important biological effects of low-dose ionizing radiation (LDIR) in mammalian cell lines. LDIR is considered as a promising assistant method of clinical cancer therapy. The purpose of this study was to evaluate the efficiency of intermittent LDIR followed by a high-dose radiation therapeutic approach compared with the conventional high-dose radiotherapy in the breast cancer MDA-MB-231 cell line.Materia...
Source: Journal of Radiation Oncology - May 25, 2019 Category: Cancer & Oncology Source Type: research

Fast in situ image reconstruction for proton radiography
ConclusionWe have demonstrated, through computer simulations of proton irradiation of a pediatric head phantom using the newly built pRad detector and image reconstruction software, that high-quality proton radiographs can be generated for patient alignment and verification of water equivalent thickness of the patient before each treatment. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - May 25, 2019 Category: Cancer & Oncology Source Type: research

Whiteboard patient tracking system improves radiation oncology treatment planning workflow
In this study, we compare the time required for completion of several components of this process, before and after whiteboard implementation, hypothesizing that whiteboard usage would decrease the time required to complete the designated task, thereby improving workflow.MethodsWe retrospectively reviewed dosimetric workflow data from 578 patients treated between January 2015 and January 2017 (320 pre- and 258 post-whiteboard). The whiteboard system cataloged various patient clinical factors as well as workflow metrics. Departmental workflow was then examined and time from simulation date to contour approval, plan approval,...
Source: Journal of Radiation Oncology - May 6, 2019 Category: Cancer & Oncology Source Type: research

Changes in prostate-specific antigen midway through salvage radiotherapy may be associated with long-term outcomes
ConclusionsPSA changes by the midpoint of SRT predict long-term prostate cancer control with increases in PSA associated with decreased freedom from disease progression. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - May 2, 2019 Category: Cancer & Oncology Source Type: research

Lymphopenia as a predictor of survival in chemoradiation-treated stage III non-small-cell lung cancer (NSCLC): a multi-center retrospective analysis
AbstractBackgroundConcurrent chemoradiation (CRT) with a platinum-containing regimen is considered standard of care for eligible unresectable stage III non-small-cell lung cancer (NSCLC) patients. Attempts to improve locoregional control, and thereby enhance overall survival (OS), by increasing the dose of radiation failed to do so in a contemporary phase III trial. Better understanding of the effects of radiation on the immune system, particularly absolute lymphocyte counts (ALC), may explain the poorer survival seen with high-dose (HD) radiation compared to low dose (LD). We hypothesized that treatment-induced lymphopeni...
Source: Journal of Radiation Oncology - April 29, 2019 Category: Cancer & Oncology Source Type: research

Adjuvant chemoradiation in resected gallbladder cancer: a prognostic index model for predicting overall survival
AbstractPurposePatients with gallbladder cancer (GBC) have a dismal prognosis. We investigated outcomes and risk factors for overall survival (OS) in patients treated with radical surgery and adjuvant chemoradiotherapy (CRT).Materials/methodsA total of 212 patients with LAGC ( ⩾pT3 59% and/or pN+ 52%) were studied. The primary endpoint of the analysis was OS. We constructed a risk scoring system in which points were assigned to each risk factor by dividing each β coefficient in the final model by the lowest β coefficient and rounding to the nearest integer. A risk sco re was assigned to each subject by adding u...
Source: Journal of Radiation Oncology - March 26, 2019 Category: Cancer & Oncology Source Type: research

Correction to: Stereotactic body radiation therapy for non-small cell lung cancer patients with prior history of thoracic surgery and/or radiation therapy: the influence of smoking, size, and central location on risk of complications
The article Stereotactic body radiation therapy for non-small cell lung cancer patients with prior history of thoracic surgery and/or radiation therapy: the influence of smoking, size, and central location on risk of complications. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - March 23, 2019 Category: Cancer & Oncology Source Type: research

Comparison of deep inspiration breath hold and free breathing technique in left breast cancer irradiation: a dosimetric evaluation in 40 patients
ConclusionOur study confirms the DIBH technique advantage in reducing cardiac and pulmonary doses for tangentially treated left-sided breast cancer patients. Further research is warranted to evaluate potential long-term clinical implications of these relevant dosimetry results. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - March 19, 2019 Category: Cancer & Oncology Source Type: research

Reconstructed and real proton radiographs for image-guidance in proton beam therapy
AbstractOne of the major challenges to proton beam therapy at this time is the uncertainty of the true range of a clinical treatment proton beam as it traverses the various tissues and organs in a human body. This uncertainty necessitates the addition of greater “margins” to the planning target volume along the direction of the beam to ensure safety and tumor target coverage.Proton radiography holds promise as both an image-guidance method for proton beam therapy and as a means of estimating particle beam range in the clinic. In this brief report, we present some of the first real and reconstructed proton radio...
Source: Journal of Radiation Oncology - March 19, 2019 Category: Cancer & Oncology Source Type: research

Use of the neutrophil to lymphocyte ratio (NLR) and the platelet to lymphocyte ratio (PLR) for prognostication of patients with early-stage non-small cell lung cancer (NSCLC) treated with stereotactic body radiation therapy (SBRT): a systematic review
ConclusionNLR and PLR appear to be relevant prognostic factors for OS following lung SBRT in stage I NSCLC. They may serve as accessible and inexpensive tests to aid in clinical decision-making but prospective validation is necessary. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - March 19, 2019 Category: Cancer & Oncology Source Type: research

Prostate radiotherapy effects on testosterone levels: an empirical investigation
AbstractObjectiveThere is a paucity of clinical data to support the hypothesis that external beam radiation therapy causes iatrogenic hypogonadism in prostate cancer patients.MethodsAll prostate cancer patients treated at a single institution with radiation therapy between 2002 and 2010 were retrospectively evaluated. Patients treated with brachytherapy alone received 0  Gy of external beam radiation therapy and served as the control group. Patients treated with combination external beam radiation therapy + brachytherapy, or external beam radiation therapy alone were categorized into groups who received 45–54&nb...
Source: Journal of Radiation Oncology - March 18, 2019 Category: Cancer & Oncology Source Type: research