Sex-dependent association of ACE (I/D) polymorphism with Meniere's disease

Publication date: Available online 29 January 2020Source: Meta GeneAuthor(s): Mohammad Mohseni, Nasrin Yazdani, Saeedeh Asgarbeik, Ahmad Daneshi, Mohammad Farhadi, Ali Mohammad Asghari, Saleh Mohebbi, Aida Vahidi, Mahsa Mohammad AmoliAbstractBackgroundMeniere's disease is an inner ear disorder presenting with recurrent episodic vertigo, fluctuating sensorineural hearing loss, tinnitus, and aural fullness as its main symptoms. Previous studies have demonstrated the role of blood pressure in Meniere's disease. The purpose of this study was to determine the role of ACE, rs4646994 I/D polymorphism in Meniere's disease.Methods and materialsIn this case-control study, 67 individuals with Meniere's disease and 100 healthy individuals as a control group were enrolled. Patients DNA samples were extracted from the blood by the phenol-chloroform method. The frequency of genotypes were determined by polymerase chain reaction (PCR) technique.ResultsThe genotypes and allele frequencies were not significantly different between the studied populations (p > .05). There was significant differences for distribution of I/D genotype between females and males (p 
Source: Meta Gene - Category: Genetics & Stem Cells Source Type: research

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The search for an effective medication that will eliminate tinnitus has a long history. Currently, no drugs exist that universally cure tinnitus. Pharmacologic interventions that have been investigated can be divided into those that attempt to eliminate the perception of tinnitus, and those that are designed to treat the negative comorbidities associated with tinnitus, thereby mitigating tinnitus ’ negative impact on quality of life. A third category of drugs can also be considered that addresses an identified pathologic condition that has tinnitus as an associated symptom (for example, Meniere’s disease, otosc...
Source: Otolaryngologic clinics of North America - Category: ENT & OMF Authors: Source Type: research
What is tinnitus? Tinnitus is a generic term used to describe a ringing or noise in the ears that occurs in the absence of external sound. This is a very common condition that is thought to occur in up to 15% of people. It can occur in one or both ears, and often people will describe the sound as “coming from their head.” There are a variety of descriptions that people use for their tinnitus such as whooshing, ringing, pulsing, and/or buzzing, and the quality of the sound varies by individual. Symptoms of tinnitus can cause great distress While tinnitus can be caused by conditions that require medical attention...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Ear, nose, and throat Hearing Loss Tests and procedures Source Type: blogs
DiscussionOur planned systematic review will provide informative evaluations of existing treatments for management of Meniere ’s disease. The findings will inform practitioners as to the relative benefits and harms of the existing competing interventions for MD, offer optimal clinical treatment strategies, identify evidence gaps, and determine promising therapies for evaluation in future trials.Systematic review registrationPROSPEROCRD42019119129
Source: Systematic Reviews - Category: International Medicine & Public Health Source Type: research
Semin Neurol DOI: 10.1055/s-0039-3402065Meniere's disease (MD) is a set of uncommon disorders with core phenotype of tinnitus, episodic vertigo, and sensorineural hearing loss. MD shows a genetic predisposition and a family history is found in 10% cases, with an autosomal dominant inheritance pattern. It is a multifactorial condition whose onset and development are triggered by the combined effect of genetic and environmental factors. Histopathological studies have associated MD with the accumulation of endolymph in the cochlea and the vestibular organs. However, endolymphatic hydrops does not fully explain the persistence...
Source: Seminars in Neurology - Category: Neurology Authors: Tags: Review Article Source Type: research
Publication date: Available online 22 November 2019Source: Brazilian Journal of OtorhinolaryngologyAuthor(s): Lívia Noleto de Rezende Oliveira, Cleydson Lucena de Andrada Oliveira, Karen de Carvalho Lopes, Fernando Freitas GanançaAbstractIntroductionMeniere's disease is a labyrinth disease that usually presents with episodes of spontaneous vertigo associated with sensorineural hearing loss, tinnitus and ipsi- and unilateral aural fullness in most cases. Vestibular function tests, video-Head-Impulse Test and the Caloric Test, are not specific for diagnosis of the disease, but may show alterations that help to ...
Source: Brazilian Journal of Otorhinolaryngology - Category: ENT & OMF Source Type: research
ConclusionOur study shows a reduced number of vertigo attacks and a positive effect on the discomfort generated by tinnitus and quality of life in patients with unilateral MD treated with SPC and when compared to patients treated with intravenous glycerol and dexamethasone. No effects on hearing thresholds were noted in both groups.
Source: European Archives of Oto-Rhino-Laryngology - Category: ENT & OMF Source Type: research
Publication date: Available online 19 August 2019Source: Operative Techniques in Otolaryngology-Head and Neck SurgeryAuthor(s): Jenny X. Chen, Zizi Yu, Steven D. RauchMeniere's disease is characterized by idiopathic progressive fluctuating hearing loss, tinnitus, and episodic vertigo. Intratympanic gentamicin injection is the preferred therapeutic option for those who have failed conservative management including lifestyle modifications and oral medications. The procedure is simple and can be performed in the outpatient setting under local anesthesia with manageable recovery time. Patients may experience a disequilibrium s...
Source: Operative Techniques in Otolaryngology Head and Neck Surgery - Category: ENT & OMF Source Type: research
Publication date: Available online 26 April 2019Source: Journal of Acupuncture and Meridian StudiesAuthor(s): Warangkana Arpornchayanon, Supanimit TeekachunhateanAbstractRole of electroacupucture (EA) in refractory unilateral sensorineural hearing loss (SNHL) remains unclear but might be promising for the Meniere’s disease (MD). Two cases of unilateral SNHL who were unresponsive to conventional treatment of sudden SNHL showed complete recovery after receiving EA therapy. The first case was a 46-year-old female who received EA in the seventh month after the acute onset of sudden right hearing loss and tinnitus. She ha...
Source: Journal of Acupuncture and Meridian Studies - Category: Complementary Medicine Source Type: research
In conclusion, for the radiological assessment of TB fractures, the entire VA should be regarded as a part of the otic capsule, and delayed inner ear sequelae should be anticipated for retrolabyrinthine fracture lines that course into or through the VA. When considering treatment options in cases similar to the present, our findings suggest that surgical interventions targeting the eES (ES shunting/decompression procedures (31–33), which are used in MD with the intention to drain the hydropic endolymphatic fluid space, or to improve the fluid resorptive functions of the eES, respectively, most likely cannot work as p...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Publication date: Available online 20 December 2018Source: Brazilian Journal of OtorhinolaryngologyAuthor(s): Xuanyi Li, Qianru Wu, Yan Sha, Chunfu Dai, Ru ZhangAbstractIntroductionMeniere's disease is associated with impaired hearing, tinnitus, vertigo, and aural fullness. Many anatomical studies have suggested idiopathic endolymphatic hydrops as the pathological basis of Meniere's disease, which now can be visualized by using gadolinium -enhanced magnetic resonance imaging of the inner ear.ObjectiveTo investigate the development of endolymphatic hydrops in Meniere's disease by monitoring the vestibules and cochleae of af...
Source: Brazilian Journal of Otorhinolaryngology - Category: ENT & OMF Source Type: research
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