Integrating Next Generation Sequencing with Morphology Improves Prognostic and Biologic Classification of Spitz Neoplasms

The newest WHO classification suggests eliminating cases with BRAF and NRAS mutations from the categories of Spitz tumors (ST) and Spitz melanoma (SM). We aimed to better characterize the genomics of Spitz neoplasms and assess whether integrating genomic data with morphologic diagnosis improves classification and prognostication. We performed DNA and RNA sequencing on 80 STs, 26 SMs, and 22 melanomas with Spitzoid features (MSF). NGS data was used to reclassify tumors by moving BRAF/NRAS-mutated cases to MSF.

Source: Journal of Investigative Dermatology - January 27, 2020 Category: Dermatology Authors: Victor L. Quan, Bin Zhang, Yongzhan Zhang, Lauren S. Mohan, Katherine Shi, Annette Wagner, Lacey Kruse, Timothy Taxter, Nike Beaubier, Beaubier, Kevin White, Lihua Zou, Pedram Gerami Tags: Original Article Source Type: research