Predicting Therapeutic Antibody Delivery into Human Head and Neck Cancers.

CONCLUSIONS: This study provides a clinically translatable platform to measure antibody delivery into solid tumors and yields valuable insight into clinically relevant antibody tumor penetration, with implications in the selection of patients amenable to antibody therapy and the design of more effective dosing strategies.
PMID: 31980465 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - January 23, 2020 Category: Cancer & Oncology Authors: Lu G, Fakurnejad S, Martin BA, van den Berg NS, van Keulen S, Nishio N, Zhu AJ, Chirita SU, Zhou Q, Gao RW, Kong CS, Fischbein N, Penta M, Colevas AD, Rosenthal EL Tags: Clin Cancer Res Source Type: research