P158 loss of autotaxin alters innate and adaptive immune mechanism and promotes spontaneous colitis in il10-ko mice

Autotaxin (Atx) is a secreted enzyme converting lysophosphatidylcholine (LPC) and sphingosyl-phosphorylcholine into lysophosphatidic acid and sphingosine 1-phosphate, respectively. Given the high affinity of LPC to cholesterol and the enrichment of cholesterol and sphingolipids in lipid rafts wherein LPS sensor Toll-like receptor 4 (TLR4) and its co-receptor CD14 reside, we hypothesized that Atx deficiency inhibits TLR4-mediated innate and adaptive immunity; thereby, accelerating the susceptibility to microbe-induced intestinal inflammation.
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Innate and Mucosal Immunology and Immunity Source Type: research