Use of GRADE for assessment of evidence about prognostic factors: rating certainty in identification of groups of patients with different absolute risks

The Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach to rating certainty in the results of research studies was initially developed for therapeutic questions. The approach considers: study design, risk of bias; inconsistency; imprecision; indirectness, publication bias; magnitude of effect; and dose-response.Questions about prognosis bear great relevance for decision-making in health care. Studies of prognosis can inform individuals about their likely outcome: for instance, in patients with a new diagnosis of cancer, are they likely to be alive or dead in five years.

Source: Journal of Clinical Epidemiology - January 22, 2020 Category: Epidemiology Authors: Farid Foroutan, Gordon Guyatt, Victoria Zuk, Per Olav Vandvik, Ana Carolina Alba, Reem Mustafa, Robin Vernooij, Ingrid Rodriguez, Zachary Munn, Pavel Roshanov, Richard Riley, Stefan Schandelmaier, Ton Kujipers, Reed Siemieniuk, Carlos Canelo Avbar, Holger Tags: Original Article Source Type: research