Persica 002 Phase 1b PP353 vs Placebo in the Treatment of Low Back Pain

Condition:   Chronic Low-back Pain Interventions:   Drug: PP353;   Drug: PP353-B Sponsors:   Persica Pharmaceuticals Ltd;   Micron Research Ltd Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

Related Links:

Conclusions: The proposed web-based deep learning approach can be very practical and accurate for spine segmentation as a diagnostic method. PMID: 32082701 [PubMed]
Source: Healthcare Informatics Research - Category: Information Technology Tags: Healthc Inform Res Source Type: research
This study was designed by researchers at X University.Participants: Thirty-seven patients undergoing LSS were randomized to motor imagery group (n=19) and control group (n=18).Main Outcome Measures: Pain was measured by Visual Analogue Scale, disability related to low back pain by Oswestry Disability Index, pain-related fear by Tampa Scale of Kinesiophobia, depression by Beck Depression Inventory, quality of life by World Health Organization Quality of Life Scale-Short Form (WHOQOL-BREF). All assessments were repeated in the preoperative period, three weeks after and six weeks after the surgery.Interventions: Motor imager...
Source: EXPLORE: The Journal of Science and Healing - Category: Complementary Medicine Source Type: research
We present a case report of an adult woman with AKL-positive ALCL, diagnosed by endobronchial ultrasound-guided transbronchial needle aspirate (EBUS-TBNA).A 59-year-old women with no history of breast implants, was admitted for a four-month low back pain. Initially, the patient was treated for a spondyloarthropathy, but due to persistence of the symptoms, a lumbosacral MRI was performed, showing changes in morphology and signal intensity in the vertebral body of L3, along with edema and a paravertebral collection that affected the left psoas muscle, suggesting granulomatous spondylodiscitis. Chest CT-scan showed mild left ...
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
This study investigated whether various forms of conceptually oriented pre-processing or the preselection of established factors was superior to using all factors as input.
Source: Journal of Clinical Epidemiology - Category: Epidemiology Authors: Tags: Original Article Source Type: research
Condition:   Low Back Pain Interventions:   Other: osteopathic treatment + cognitive training;   Other: osteopathic treatment;   Other: usual care Sponsors:   Come Collaboration;   Hospital General Universitario Santa Lucia;   Niguarda Hospital;   Orthoplus Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Source: BMJ Comments - Category: General Medicine Source Type: forums
Conclusions: Our results can help direct health care professionals advice for women who are planning pregnancy towards walking as it seems to be sustained during pregnancy.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
The sacroiliac joint is an important source of low back pain. In severe cases, sacroiliac joint fusion is used to reduce pain, but revision rates can reach 30%. The lack of initial mechanical stability may lead to pseudarthrosis, thus not alleviating the patient's symptoms. This could be due to the damage induced to the interosseous ligament during implant insertion. Decoupling instrumentation steps (drilling-tapping and implant insertion) would allow verifying this hypothesis. Moreover, no biomechanical studies have been published on sacroiliac joint fixation with an oblique lateral approach, while it has important clinic...
Source: Clinical Biomechanics - Category: Orthopaedics Authors: Source Type: research
Altered pronociceptive and antinociceptive mechanisms are often implicated in painful conditions and have been increasingly studied over the past decade. For some painful conditions, alterations are well-established, but in populations with low back pain (LBP), there remains considerable debate whether these mechanisms are altered. The present systematic review aimed to address this issue by identifying studies assessing conditioned pain modulation (CPM) and/or temporal summation of pain (TSP) in patients with LBP, comparing with either a healthy control group or using a method with reference data available. Qualitative sy...
Source: Pain - Category: Anesthesiology Tags: Systematic Review and Meta-Analysis Source Type: research
In conclusion, parents and coaches should be properly re-educated to help improve lower back, upper extremity, and shoulder pain among young basketball players. PMID: 32062615 [PubMed - in process]
Source: The Tohoku Journal of Experimental Medicine - Category: Research Authors: Tags: Tohoku J Exp Med Source Type: research
More News: Back Pain | Low Back Pain | Pain | Research