Old and new genes in primary aldosteronism

Publication date: Available online 22 January 2020Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Sheerazed Boulkroun, Fabio Luiz Fernandes-Rosa, Maria-Christina ZennaroAbstractPrimary aldosteronism (PA) is the most common form of secondary hypertension affecting 5% to 10% of patients with arterial hypertension. In PA, high blood pressure is associated with high aldosterone and low renin levels, and often hypokalemia. In a majority of cases, autonomous aldosterone production by the adrenal gland is caused by an aldosterone producing adenoma (APA) or bilateral adrenal hyperplasia (BAH). During the last ten years, a better knowledge of the pathophysiology of PA came from the discovery of somatic and germline mutations in different genes in both sporadic and familial forms of the disease. Those genes code for ion channel and pumps, as well as proteins involved in adrenal cortex development and function. Targeted next generation sequencing following immunohistochemistry guided detection of aldosterone synthase expression allows detection of somatic mutations in up to 90% of APA, while whole exome sequencing has discovered the genetic causes of four different familial forms of PA. The identification, in BAH, of somatic mutations in aldosterone producing cell clusters open new perspectives in our understanding of the bilateral form of the disease and the development of new therapeutic approaches.

Source: Best Practice and Research Clinical Endocrinology and Metabolism - January 23, 2020 Category: Endocrinology Source Type: research