Impulse Dynamics moving to expanded HQ after raising $80.25M

The company's working to commercialize its implantable cardiac device used to treat chronic heart failure.
Source: Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news

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Heart failure (HF) is a leading cause of mortality and hospital readmissions in the United States. A large proportion of these patients are readmitted from skilled nursing facilities (SNF). The implementation of quality initiatives, such as staff education, to recognize early measures of clinical instability could improve HF management at these facilities.
Source: Journal of the American Medical Directors Association - Category: Health Management Authors: Source Type: research
Publication date: April 2020Source: IJC Heart &Vasculature, Volume 27Author(s): Michele Correale, Adriana Mallardi, Pietro Mazzeo, Lucia Tricarico, Claudia Diella, Valentina Romano, Armando Ferraretti, Alessandra Leopizzi, Giuseppina Merolla, Matteo Di Biase, Natale Daniele Brunetti
Source: IJC Heart and Vasculature - Category: Cardiology Source Type: research
Authors: Davila CD, Udelson JE Abstract Heart failure (HF) represents the most common cause of hypervolemic hyponatremia in current clinical practice. The presence of hyponatremia has been independently associated with worse outcomes in this patient population. The pathogenesis of hyponatremia in HF involves complex neurohormonal and cardio-renal interactions, including an increase in non osmotic secretion of arginine vasopressin (AVP) and insufficient tubular flow in the diluting segments of the nephron. The treatment of hyponatremia in HF involves decongestant therapy with diuretics, neurohormonal blockade and in...
Source: Frontiers of Hormone Research - Category: Endocrinology Tags: Front Horm Res Source Type: research
Takotsubo cardiomyopathy, also known as broken heart syndrome, apical ballooning syndrome, or stress cardiomyopathy, occurs when a stressful emotional or physical event causes the left ventricle of the heart to dilate, leading to acute heart failure. The syndrome was first described in Japan in 1990. Signs and symptoms of Takotsubo cardiomyopathy are similar to acute myocardial infarction. The syndrome presents with similar ECG and biomarker indications, so it often goes undiagnosed until coronary angiography is performed and reveals no blockage. Treatment is largely supportive. Angiotensin-converting enzyme (ACE) inhibito...
Source: Journal of the American Academy of Physician Assistants - Category: Primary Care Tags: CME: Cardiology Source Type: research
(Mayo Clin Proc. 2019;94(5):811–819)
Source: Obstetric Anesthesia Digest - Category: Anesthesiology Tags: Epidemiologic Reports Surveys Source Type: research
Contributors : Rebecca Windmueller ; Micheal P Morley ; Edward E MorriseySeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe mammalian heart is incapable of regenerating a sufficient number of cardiomyocytes to ameliorate the loss of contractile muscle after acute myocardial injury, often resulting in heart failure. Several reports have demonstrated that mononucleated (MoNuc) cardiomyocytes are more responsive to pro-proliferative stimuli than are binucleated (BiNuc) cardiomyocytes. However, techniques to isolate and characterize these two different cardiomyocyte populations have been...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Contributors : Willian A da Silveira ; Gary HardimanSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicus albusRosiglitazone is a member of the thiazolidinedione class of drugs, an anti-diabetic drug known for being a ligand of peroxisome proliferation activating receptors γ (PPARγ), a group of nuclear hormone receptors that are involved in the regulation of genes related to glucose and lipid metabolism. The use of Rosiglitazone has been shown to increase the risk of congestive heart failure in type II diabetes patients due to increased fluid retention and plasma vo lume. ...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Rattus norvegicus albus Source Type: research
Authors: La Rovere MT, Traversi E Abstract The implantable cardioverter-defibrillator (ICD) is the mainstay therapy for primary prevention of sudden cardiac death in patients with heart failure with a reduced ejection fraction. Current indications for prophylactic ICD are based on the results of randomized controlled trials dating back to 15-20 years ago, which have usually enrolled highly selected patients with few comorbidities and only a small number of patients aged>75 years. Existing literature suggest an age-dependent attenuation of the efficacy of the ICD. Because of the ageing of the population, there is...
Source: Monaldi Archives for Chest Disease - Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research
Conclusion: These cases suggest the incidence of a clinical entity strongly reminiscent of Takotsubo phenomenon of atypical topography as a consequence of diving accidents. PMID: 32089094 [PubMed - as supplied by publisher]
Source: Acta Cardiologica - Category: Cardiology Tags: Acta Cardiol Source Type: research
Publication date: Available online 24 February 2020Source: Journal of Sport and Health ScienceAuthor(s): Sudhir Kurl, Sae Young Jae, Timo H. Mäkikallio, Ari Voutilainen, Magnus J. Hagnäs, Jussi Kauhanen, Jari A Laukkanen
Source: Journal of Sport and Health Science - Category: Sports Medicine Source Type: research
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