Rapid quantification of tenofovir in umbilical cord plasma and amniotic fluid in hepatitis B mono-infected pregnant women during labor by Ultra Performance Liquid Chromatography/Tandem Mass Spectrometry.

CONCLUSIONS: A simple, rapid but sensitive bioanalytical method to determine TFV concentration in both umbilical cord plasma and amniotic fluid using LC/MS/MS was developed and applied to HBV-infected women during labor who were undergoing TDF therapy, which will help us understand the efficacy and safety of tenofovir during pregnancy. PMID: 31960519 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31960519?dopt=Abstract

Source: Rapid Communications in Mass Spectrometry : RCM - January 19, 2020 Category: Chemistry Authors: Ma Z, Li S, He D, Wang Y, Jiang H, Zhou H, Jin J, Lin N Tags: Rapid Commun Mass Spectrom Source Type: research