Overexpression of aromatase associated with loss of heterozygosity of the STK11 gene accounts for prepubertal gynecomastia in boys with Peutz Jeghers Syndrome.

Conclusions:LOH of the STK11 gene leads to an increase in aromatase expression associated with an increase in CRTC nuclear localization, thereby providing a mechanism whereby PJS results in increased endogenous estrogens in affected males.
PMID: 24037887 [PubMed - as supplied by publisher]

Source: The Journal of Clinical Endocrinology and Metabolism - September 13, 2013 Category: Endocrinology Authors: Ham S, Meachem SJ, Choong CS, Charles AK, Baynam GS, Jones TW, Samarajeewa NU, Simpson ER, Brown KA Tags: J Clin Endocrinol Metab Source Type: research