Dual effect of 5-HT1B/1D receptors on dopamine neurons in ventral tegmental area: implication for the functional switch after chronic cocaine exposure

5-HT1B/1D receptor (5-HT1B/1DR) agonists undergo an abstinence-induced “switch” in their effects on cocaine-related behaviors, which may involve changes in modulation of dopamine (DA) neurons in the ventral tegmental area (VTA). However, it is unclear how 5-HT1B/1DRs affect VTA DA neuronal function, and whether modulation of these neurons mediates the abstinence-in duced switch after chronic cocaine exposure.

Source: Biological Psychiatry - January 21, 2020 Category: Psychiatry Authors: Ming Gao, Taleen S. Der-Ghazarian, Shuangtao Li, Shenfeng Qiu, Janet L. Neisewander, Jie Wu Tags: Archival Report Source Type: research