Circular RNA 0007255 regulates the progression of breast cancer through miR ‐335‐5p/SIX2 axis

ConclusionCirc_0007255 functioned as a novel oncogene in the progression of BC by regulating miR ‐335‐5p/SIX2 axis, and might be a promising biomarker for BC treatment.Key pointsSignificant findings of the study: Levels of circ_0007255 and SIX2 were upregulated, but miR ‐335‐5p was diminished in BC tissues and cells. Circ_0007255 was an oncogene in BC development and exerted its function via miR‐335‐5p/SIX2 axis in BC. Tumor growth was reduced by circ_0007255 absence.What this study adds: Circ_0007255 functioned as a novel oncogene in the progression of BC by regulating miR ‐335‐5p/SIX2 axis, and might be a promising biomarker for BC treatment.

Source: Thoracic Cancer - January 20, 2020 Category: Cancer & Oncology Authors: Qianxin Jia, Lanlan Ye, Shangwen Xu, Hui Xiao, Siding Xu, Zhaoyin Shi, Jinsheng Li, Ziqian Chen Tags: ORIGINAL ARTICLE Source Type: research