Z-score mapping for standardized analysis and reporting of cardiovascular magnetic resonance modified Look-Locker inversion recovery (MOLLI) T1 data: Normal behavior and validation in patients with amyloidosis

T1 mapping using modified Look-Locker inversion recovery (MOLLI) provides quantitative information on myocardial tissue composition. T1 results differ between sites due to variations in hardware and software e...
Source: Journal of Cardiovascular Magnetic Resonance - Category: Radiology Authors: Tags: Research Source Type: research

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Publication date: 1 April 2020Source: Journal of Molecular Liquids, Volume 303Author(s): Syed Mohammad Zakariya, Mohammad Furkan, Masihuz Zaman, Tajalli Ilm Chandel, Syed Moasfar Ali, Vladimir N. Uversky, Rizwan Hasan KhanAbstractProtein misfolding leads to several human pathologies. So far, there has not been much success on the remediations of these protein conformational disorders. Since these diseases arise as a result of protein aggregation, hence inhibition of aggregation could be a promising approach for designing new therapeutics. For which; polyphenols, antibiotics and other small compounds have been tested by the...
Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM) Issue: Ahead of print
Source: Clinical Chemistry and Laboratory Medicine - Category: Laboratory Medicine Source Type: research
Conditions:   Amyloid;   AL Amyloidosis;   Refractory AL Amyloidosis Interventions:   Drug: Daratumumab;   Drug: Pomalidomide;   Drug: Dexamethasone Sponsors:   Weill Medical College of Cornell University;   Janssen Scientific Affairs, LLC Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Hereditary Transthyretin-mediated Amyloidosis With Polyneropathy;   Pregnancy Intervention:   Drug: inotersen Sponsor:   Akcea Therapeutics Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionsCauses for the observed mortality imbalance associated with revusiran were thoroughly investigated and no clear causative mechanism could be identified. Although the results suggest similar progression of cardiac parameters in both treatment arms, a role for revusiran cannot be excluded.Clinical Trial RegistrationNCT02319005.
Source: Cardiovascular Drugs and Therapy - Category: Cardiology Source Type: research
Conditions:   Amyloid;   AL Amyloidosis;   Refractory AL Amyloidosis Interventions:   Drug: Daratumumab;   Drug: Pomalidomide;   Drug: Dexamethasone Sponsors:   Weill Medical College of Cornell University;   Janssen Scientific Affairs, LLC Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Hereditary Transthyretin-mediated Amyloidosis With Polyneropathy;   Pregnancy Intervention:   Drug: inotersen Sponsor:   Akcea Therapeutics Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 13 February 2020Source: Revista Española de Medicina Nuclear e Imagen Molecular (English Edition)Author(s): Elena Casillas Sagrado, Francisco José Pena Pardo, Sara Palomo Cousido, Ana María García Vicente, Ángel Soriano Castrejón
Source: Revista Espanola de Medicina Nuclear e Imagen Molecular - Category: Nuclear Medicine Source Type: research
Left ventricular pressure-strain –derived myocardial work index (LVMWI) is a novel, noninvasive method for left ventricular (LV) function evaluation in relation to LV pressure dynamics. LV global longitudinal strain (LVGLS) has proven benefit for diagnosis and risk stratification in patients with cardiac amyloidosis (CA), but LVG LS does not adjust for loading conditions. The aim of the present study was to characterize LVMWI at rest and during exercise in patients with CA.
Source: Journal of the American Society of Echocardiography - Category: Cardiology Authors: Source Type: research
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Source: Amyloid: The Journal of Protein Folding Disorders - Category: Biochemistry Authors: Source Type: research
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