On the preparation and physicochemical properties of pH-responsive hydrogel nanocomposite based on poly(acid methacrylic)/laponite RDS
Publication date: June 2020Source: Materials Today Communications, Volume 23Author(s): Carlos R.F. Junior, Renan da S. Fernandes, Marcia R. de Moura, Fauze A. AouadaAbstractIn this paper, a series of novel poly(methacrylic acid)/laponite RDS (PMAA/Lap RDS) nanocomposite hydrogels crosslinked by N,N’-methylene bisacrylamide were synthesized via free radical polymerization by using potassium persulfate as initiator. The main novelty of this paper refers to the detail investigation of how the laponite RDS influenced of the pKa, and consequently, the water-uptake of these nanocomposites. In parallel, the evidence of incorporation and interactions of the materials was confirmed by scanning electron microscopy and Fourier transform infrared spectra techniques. By the X-ray diffraction technique (XRD), it was possible to confirm the exfoliation/intercalation configuration of the nanoclay laponite RDS (Lap RDS) into the PMAA matrix. Hydrophilic properties, measured by swelling degree (SD), indicated that the presence of Lap RDS influenced the water uptake capability of the nanocomposite, reaching a maximum of 91 ± 2 g/g for nanocomposites constituted by 5 % of nanoclay. Besides, the pKa of the nanocomposite can be adjusted by nanoclay content. In this way, the ability of these hydrogels to respond to pH values can be useful to act as trigger in controlled release systems.Graphical abstract
CONCLUSIONS.: Our results confirm orbitofrontal structural deficits in BPD, while providing a framework and preliminary findings on identifying structural correlates of symptom dimensions in BPD, especially with dorsolateral and orbitofrontal cortices. PMID: 32093800 [PubMed - in process]
CONCLUSIONS.: Despite sharing a lower IQ and a higher prevalence of psychiatric disorders, brain abnormalities in BDo appear less pronounced (but are not absent) than in SZo. Lower ICV in SZo implies that familial risk for schizophrenia has a stronger association with stunted early brain development than familial risk for bipolar disorder. PMID: 32093799 [PubMed - in process]
Conclusion: These updated French guidelines will contribute to increase the level of urological care for the diagnosis and treatment for NMIBC and MIBC. PMID: 32093463 [PubMed - in process]
Authors: Higuchi M Abstract The deposition of fibrillar tau aggregates has been implicated in Alzheimer's disease (AD) and allied neurodegenerative disorders collectively referred to as tauopathies. Growing non-clinical and clinical evidence has supported intimate links between tau fibrillogenesis and neuronal deteriorations, rationalizing the development of imaging agents for tau fibrils to gain etiological insights into tauopathies and to facilitate diagnostic and therapeutic approaches to these diseases. Radiochemicals derived from three major chemotypes were initially applied to positron emission tomography (PE...
Associations Between APOE Variants, Tau and α-Synuclein. Adv Exp Med Biol. 2019;1184:177-186 Authors: Rodriguez-Vieitez E, Nielsen HM Abstract Neurodegenerative diseases are characterized by the aggregation and deposition of misfolded proteins in the brain, most prominently amyloid-β (Aβ), tau and α-synuclein (α-syn), and are thus referred to as proteinopathies. While tau is a hallmark of Alzheimer's disease (AD) and other non-AD tauopathies, and α-synuclein is the pathological feature of the spectrum of synucleinopathies including Parkinson's disease (PD), Parkinson's...
Authors: Morisaki T, Fukuhara T, Matsuda E, Moritani S, Miyake N, Koyama S, Fujiwara K, Takeuchi H Abstract Lymphadenopathy is frequently observed in immunoglobulin G4 (IgG4)-related disease in some cases, and such cases are known as IgG4-related lymphadenopathy. The ultrasonography findings associated with IgG4-related lymphadenopathy have not been described in previous reports. Herein, we describe ultrasonography findings in two cases of IgG4-related lymphadenopathy in conjunction with histopathological findings. Combined ultrasound scanning with Doppler examination accurately represented the specific histopathol...
CONCLUSIONS: In cases of BCCs with thickness of ≤1 mm, there was a high correlation (r=0.870) of the tumor spread depth between micromorphological measurements and the results obtained using a 75 MHz transducer and in cases of BCCs with thickness of>1 mm, a very high correlation (r=0.951) of the tumor spread depth was observed between histomorphometry and30 MHz transducer measurements. PMID: 32096785 [PubMed - as supplied by publisher]
Publication date: 25 February 2020Source: Cell Reports, Volume 30, Issue 8Author(s): Marco Brondi, Monica Moroni, Dania Vecchia, Manuel Molano-Mazón, Stefano Panzeri, Tommaso Fellin
Authors: PMID: 32090629 [PubMed - as supplied by publisher]
Publication date: Available online 25 February 2020Source: Food ControlAuthor(s): Son Anh Vo, Joel Scanlan, Paul Turner