Therapeutic Strategies for Corneal Wound Angiogenesis

AbstractPurpose of ReviewCorneal diseases are a major cause of blindness worldwide, resulting from corneal scarring and neovascularization. There is an unmet need for developing effective therapies to prevent and/or treat corneal neovascularization.Recent FindingsTopical steroid medication, cautery, argon and yellow dye laser, and fine needle diathermy have all been advocated with varying degrees of success. Vascular endothelial growth factor family of proteins play a pivotal role in corneal neovascularization, and current therapies are aimed at disrupting the various steps in this pathway. Advancement in cell-based therapies and regulatory molecules as a therapeutic target for treating corneal neovascularization is gaining popularity.SummaryThis review focuses on the current treatment modalities, new alternative therapies, potential new targets, and insights into the future research for this debilitating condition.
Source: Current Pathobiology Reports - Category: Laboratory Medicine Source Type: research

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Authors: He M, Long P, Guo L, Zhang M, Wang S, He H Abstract Aims: Diabetic retinopathy (DR) remains one of the leading causes of acquired blindness. Fushiming capsule (FSM), a compound traditional Chinese medicine, is clinically used for DR treatment in China. The present study was to investigate the effect of FSM on retinal alterations, inflammatory response, and oxidative stress triggered by diabetes. Main Methods: Diabetic rat model was induced by 6-week high-fat and high-sugar diet combined with 35 mg/kg streptozotocin (STZ). 30 days after successful establishment of diabetic rat model, full field electror...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Authors: Andrade-Cetto A, Cruz EC, Cabello-Hernández CA, Cárdenas-Vázquez R Abstract Type 2 diabetes (T2D) is a major health problem worldwide. In this condition, the organism can produce insulin but becomes resistant to it; thus the insulin is ineffective. High blood glucose levels are a result of insulin resistance and insulin deficiency; they produce diabetes-associated complications such as kidney failure, blindness, cardiovascular disease, and lower-limb amputation. In Guatemala, there were over 752.700 cases of the disease in 2017 with prevalence of 8.4 (IDF, 2017). The use of plants for ...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Authors: Yao Q, Yang Y, Lu X, Zhang Q, Luo M, Li PA, Pan Y Abstract Diabetic retinopathy (DR) has become the most frequent cause of impaired visual acuity and blindness in working-age population in developed countries. Here we use diabetic rats to clarify the role of Lycium barbarum polysaccharides (LBP) on DR. We treated diabetic rats with LBP (400 mg/kg/d or 200 mg/kg/d) orally for 20 weeks. Electroretinogram (ERGs) and Laser Doppler blood flow were measured to assess the retinal function, routine histology and ultrastructural studies were performed to evaluate the morphological alterations, and imm...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Conclusions: Artificial reproduction of Descemet membrane with respect to topography and similar stiffness offers a potential innovative way to bioengineer a functional CEC monolayer from autologous stem cells.
Source: Cornea - Category: Opthalmology Tags: Basic Investigation Source Type: research
By 2050, an estimated 1/3 of US adults will have type 2 diabetes mellitus (T2DM) [1]. Unfortunately, co-morbidities of T2DM such as cardiovascular diseases, neuropathy, sleep apnea, blindness and depression, are all conditions that hasten mortality leading to 1 in 5 people dying as a result [1]. Pharmaceutical therapies for treating hyperglycemia in people with T2DM often have serious adverse side effects [2]. Lifestyle approaches offer alternative or complementary therapy to pharmaceutical treatment.
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - Category: Biomedical Science Authors: Source Type: research
By 2050, an estimated one third of US adults will have type 2 diabetes mellitus (T2DM) [1]. Unfortunately, co-morbidities of T2DM include cardiovascular diseases, neuropathy, sleep apnea, blindness and depression, are all conditions that hasten mortality leading to 1 in 5 people dying as a result [1]. Pharmaceutical therapies for treating hyperglycemia in people with T2DM often have serious adverse side effects [2]. Lifestyle approaches offer alternative or complementary therapy to pharmaceutical treatment.
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - Category: Biomedical Science Authors: Source Type: research
Angiogenesis is a cause of visual impairment and blindness in the wet form of age-related macular degeneration and in ischemic retinopathies. Current therapies include use of anti-VEGF agents to reduce choroidal neovascularization (CNV) and edema. These treatments are effective in most cases, but spontaneous or acquired resistance to anti-VEGF and possible adverse effects of long-term VEGF inhibition in the retina and choroid highlight a need for additional alternative therapies. Integrins αvβ3 and αvβ5, which regulate endothelial cell proliferation and stabilization, have been implicated in ocular an...
Source: FASEB Journal - Category: Biology Authors: Tags: Research Source Type: research
CONCLUSIONS: There is currently no convincing evidence that NAC reverses cataract, nor prevents progression of cataract (defined as a change in cataract appearance either for the better or for the worse). Future studies should be randomized, double-masked, placebo-controlled trials with standardised quality of life outcomes and validated outcome measures in terms of visual acuity, contrast sensitivity and glare, and large enough to detect adverse effects. PMID: 28245346 [PubMed - in process]
Source: Cochrane Database of Systematic Reviews - Category: Journals (General) Authors: Tags: Cochrane Database Syst Rev Source Type: research
This article presents a critical analysis of New Age culture. We draw on two empirical studies conducted in Israel and show that the lofty notions about freedom from the shackles of socially structured identities and the unifying potential this holds, as well as the claim regarding the basic equality of human beings, are utopian. Blindness toward ethno-national identity reinforces identification with a self-evident hegemonic perception, thereby leading to the exclusion of peripheral groups such as indigenous populations. This exclusion is manifested in the discourse symbolically as well as in the praxis of complementary an...
Source: Health: - Category: Global & Universal Authors: Tags: Articles Source Type: research
ConclusionsCacicol® has a significant in vitro antiherpetic activity and seems particularly interesting for the management of HSV‐1 resistant to acyclovir or foscarnet, especially in tissues that can receive Cacicol® by topical application (such as the cornea). Clinical studies are necessary to determine its in vivo activity and its usefulness as a promising adjunct or alternative therapy of recurrent HSK.
Source: Acta Ophthalmologica - Category: Opthalmology Authors: Tags: Abstracts from the 2016 European Association for Vision and Eye Research Conference Source Type: research
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