Retargeting Adenoviruses for Therapeutic Applications and Vaccines

AbstractAdenoviruses (Ads) are robust vectors for therapeutic applications and vaccines, but their use can be limited by differences in theirin vitro andin vivo pharmacologies. This review emphasizes that there is not just one Ad, but a whole virome of diverse viruses that can be used as therapeutics. It discusses that true vector targeting involves not only retargeting viruses, but importantly also detargeting the viruses from off ‐target cells.
Source: FEBS Letters - Category: Biochemistry Authors: Tags: REVIEW Source Type: research