LncRNA SNHG16 promotes non ‐small cell lung cancer development through regulating EphA2 expression by sponging miR‐520a‐3p

ConclusionSNHG16 promoted NSCLC development by regulating the miR ‐520a‐3p/EphA2 axis, suggesting novel insights for the pathogenesis of NSCLC and new potential therapeutic targets for the treatment of NSCLC.Key points Knockdown of SNHG16 inhibited NSCLC cell proliferation, migration, invasion and induced apoptosis in vitro as well as suppressed tumor growth in vivo. SNHG16 directly interacted with miR ‐520a‐3p. EphA2 was a target of miR‐520a‐3p. SNHG16 could regulate the expression of EphA2 by binding to miR‐520a‐3p. SNHG16 promoted NSCLC development by regulating the miR‐520a‐3p/EphA2 axis.
Source: Thoracic Cancer - Category: Cancer & Oncology Authors: Tags: ORIGINAL ARTICLE Source Type: research