A systematic review and meta-analysis of caudate lobectomy for treatment of hilar cholangiocarcinoma

Publication date: Available online 18 January 2020Source: European Journal of Surgical OncologyAuthor(s): Emrullah Birgin, Erik Rasbach, Christoph Reissfelder, Nuh N. RahbariAbstractBackgroundSurgical resection remains the only potentially curative therapy for hilar cholangiocarcinoma (CCC) patients. This meta-analysis aimed to review the current evidence on perioperative and long-term outcomes of routine caudate lobe resection (CLR) for surgical treatment of hilar CCC.MethodsA systematic literature search using MEDLINE, EMBASE and Cochrane databases was performed for studies providing comparative data on perioperative and long-term outcomes of patients undergoing resection for hilar CCC with and without CLR. The MINORS score was used for quality assessment. For time-to-event outcomes hazard ratios (HRs) and associated 95% CI were extracted from identified studies, whereas risk ratios (RRs) were calculated for overall morbidity, mortality, and resection margin status. Meta-analyses were carried out using random-effects models.ResultsEight studies involving 1350 patients met the inclusion criteria. The quality of the included studies was low to moderate. CLR resulted in significantly improved overall survival (HR 0.49; 95%CI 0.32–0.75, P 
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research

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Conclusions: TACE provided better survival benefits compared to PMCT. However, there was a disparity in prognostic factors, suggesting evaluation of the two nomograms may be supportive in modality selection. Further prospective validation studies are required for the results to be applied in clinical medicine.
Source: Hepatobiliary and Pancreatic Diseases International - Category: Gastroenterology Source Type: research
ConclusionsThere are potential benefits of treatment on both R0 rate and complete response in resected specimens. Scientific equipoise exists in relation to neoadjuvant chemoradiotherapy for PH-CCA.
Source: Hepatobiliary and Pancreatic Diseases International - Category: Gastroenterology Source Type: research
Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCC) together account for almost all cases of primary liver cancers. Differentiation between the two cancers before treatment has significant implication for interventional radiologists, who are often involved in biopsy and treatment of both lesions. The ability to differentiate HCC from CCC on imaging could decrease morbidity, decrease cost and improve clinical decision making. To this end, we intend to use radiomics to classify cases of HCC and CCC from patient MRI scans.
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Scientific Session 32 Source Type: research
To report outcomes of transarterial radioembolization (TARE) using glass microspheres for the treatment of mixed hepatocellular-cholangiocarcinoma (HCC-CC).
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Scientific e-Poster Source Type: research
To investigate safety, early imaging response, and survival analysis of radioembolization for the treatment of intrahepatic cholangiocarcinoma using ≥150 Gy MIRD (Medical Internal Radiation Dose).
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Scientific e-Poster Source Type: research
Conditions:   Bile Duct Neoplasms;   Colorectal Neoplasms Interventions:   Device: Hepatic artery infusion pump placement using the Synchromed II pump and the Codman tapered arterial catheter.;   Drug: Hepatic artery infusion pump floxuridine and dexamethasone;   Drug: Systemic chemotherapy for colorectal liver metastases;   Drug: Systemic chemotherapy for intrahepa tic cholangiocarcinoma Sponsor:   Michael J Cavnar, MD Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Background: Artificial Intelligence (AI) frameworks have emerged as a novel approach in medicine. However, information regarding its applicability and effectiveness in a clinical prognostic factor setting remains unclear.Methods: The AI framework was derived from a pooled dataset of intrahepatic cholangiocarcinoma (ICC) patients from three clinical centers (n = 1,421) by applying the TensorFlow deep learning algorithm to Cox-indicated pathologic (four), serologic (six), and etiologic (two) factors; this algorithm was validated using a dataset of ICC patients from an independent clinical center (n = 234). The model was comp...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
In conclusion, MIAT was frequently overexpressed in CCA. MIAT contributed to the growth of CCA cells by targeting miR-551b-3p/CCND1 axis. PMID: 32064660 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Pharmacology and Physiology - Category: Drugs & Pharmacology Authors: Tags: Clin Exp Pharmacol Physiol Source Type: research
Authors: Haber PK, Sia D Abstract Biliary tract cancers (BTC), which include cholangiocarcinoma (both intra- and extrahepatic) and gallbladder, represent a heterogeneous group of malignancies with relatively low-incidence and poor prognosis. Therapeutic options for BTC patients at advanced stage are severely limited and palliative chemotherapy remains the maintreatment option. In the past decade, genome profiling via next-generation sequencing of large international cohorts has paved the way for precision oncology in BTC, identifying unique molecular subtypes, recurrent mutations, and genomic rearrangements. Target...
Source: Discovery Medicine - Category: Research Tags: Discov Med Source Type: research
We reported a case of intermittent massive upper gastrointestinal bleeding in a 33-year-old man with cholangiocarcinoma who underwent surgical resection followed by chemoradiation. A portoduodenal fistula due to chronic duodenal ulceration was identified. The bleeding was successfully controlled by endoscopic ultrasound-guided coil placement through the duodenal bulb using the anchoring technique. Follow-up endoscopy and computed tomography scan showed multiple coil placements between a part of the portal vein and the duodenal bulb without any evidence of portal vein thrombosis. There were no complications, and bleeding di...
Source: Clinical Endoscopy - Category: Gastroenterology Tags: Clin Endosc Source Type: research
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