Persistence of Denosumab Terapy among Patients with Osteoporosis.

Persistence of Denosumab Terapy among Patients with Osteoporosis. Asian Spine J. 2020 Jan 17;: Authors: Kobayash K, Ando K, Machino M, Morozumi M, Kanbara S, Ito S, Inoue T, Yamaguchi H, Ishiguro N, Imagama S Abstract Study Design: Retrospective study in a single center. Purpose: To examine denosumab persistence in patients of different ages with severe osteoporosis in Japan. Overview of Literature: Denosumab is an antibody drug used for the treatment of osteoporosis. It is mainly used in patients with severe osteoporosis who might have high motivation for treatment, and the need for only semi-annual subcutaneous injection might improve the continuation rate. However, no English-language articles have reported on denosumab persistence in the Japanese population, including young people, despite the importance of this issue in a super-aging society. Methods: The subjects started treatment with subcutaneous denosumab in our department from July 2013 until December 2017. Persistence rates were calculated using Kaplan-Meier curves. Patients were defined as "persistent" or "non-persistent" according to the use of therapy after 60 months. Results: The study included 101 patients (84 females) with a median follow-up period of 23.6±14.2 months. The persistence rate declined to 85.3%, 78.3%, 74.1%, 71.3%, and 69.3% at 12, 24, 36, 48, and 60 months, respectively. Age at the initiation of denosumab therapy differed significa...
Source: Asian Spine Journal - Category: Orthopaedics Tags: Asian Spine J Source Type: research

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Condition:   Postmenopausal Osteoporosis Intervention:   Drug: Binosto 70Mg Effervescent Tablet Sponsors:   251 Hellenic Air Force & VA General Hospital;   Laikο General Hospital, Athens;   424 General Military Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Intriago M, Maldonado G, Guerrero R, Messina OD, Rios C Abstract Objective: To study the association between osteoporosis and sarcopenia and determine the prevalence of osteosarcopenia in patients who attended a rheumatology center in Ecuador. Methods: A cross-sectional study was conducted in a population of patients who had a densitometric study. The diagnosis of sarcopenia was determined by the DXA standard gold test, screening, and conventional methods (bioimpedance, anthropometric measurements, SARC-F, muscle function, and gait test). Results: A total of 92 patients were studied. The median age...
Source: Journal of Aging Research - Category: Geriatrics Tags: J Aging Res Source Type: research
AbstractPurpose of ReviewThe aim of this narrative review is to summarise recent literature on the effects of exercise and nutrition interventions alone or in combination on muscle and bone loss in people with cancer.Recent FindingsThere is emerging evidence to support the inclusion of targeted exercise and nutrition strategies to counter loss of muscle and bone associated with cancer treatments. Although research in this field is advancing, the optimal exercise and nutrition prescription to combat cancer-related bone and muscle loss remain unknown.SummaryThis review identifies specific components of nutrition and exercise...
Source: Current Osteoporosis Reports - Category: Orthopaedics Source Type: research
ConclusionThis KPI set compliments the existing Best Practice Framework to support FLSs to examine their own performance using patient-level data. By using this KPI set for local quality improvement cycles, FLSs will be able to efficiently realise the full potential of secondary fracture prevention and improved clinical outcomes for their local populations.
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
Source: Clinical Interventions in Aging - Category: Geriatrics Tags: Clinical Interventions in Aging Source Type: research
In this study, we showed that osteoporosis is highly associated with reduction in hematopoietic autophagy activity in humans. We showed that an autophagy defect in the hematological system leads to severe bone loss. The disturbed osteocyte homeostasis is apparently caused by impaired type H blood vessels and possibly an aberrant alteration in the extracellular matrix (ECM) pathways that govern osteocyte homeostasis in hematopoietic autophagy-defective mice. Our results thus suggest that autophagy in the adjacent hematopoietic cells is essential to maintain bone homeostasis, and chronic hematopoietic autophagy deficiency ca...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
(Natural News) Fasting can improve reproductive and mental health, as well as lower the risk of musculoskeletal disorders in women, according to a recent review published in the Journal of Mid-Life Health. Researchers from the National Institute of Naturopathy in India found evidence that fasting not only prevents metabolic disorders, but it also improves bone health. The...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
AbstractFragility hip fractures and their associated morbidity and mortality pose a global healthcare problem. Several pharmaceutical products have been postulated to alter bone architecture and contribute to fragility hip fractures. We searched four electronic databases from inception to September 2017. Inclusion criteria were the following: (1) adult patients with fragility hip fractures, (2) full text in English, (3) minimum one-year follow-up, and (4) reporting of at least one risk factor. To minimize heterogeneity among the studies, we performed subgroup analyses. Whenever heterogeneity remained significant, we employ...
Source: Calcified Tissue International - Category: Orthopaedics Source Type: research
Conclusion: The new algorithm performed satisfactorily in identifying the risk of osteoporosis among the Malaysian population ≥50 years. Further validation studies are required before applying this algorithm for screening of osteoporosis in public.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
AbstractSummaryThe prevalence of unknown vertebral fractures evaluated by systematic vertebral fracture assessment (VFA) was 21% in patients over 50  years of age who suffered from a recent low-trauma non-severe peripheral fracture. The outcome of VFA resulted in changes in the management of osteoporosis.IntroductionThe aim of this study was to evaluate the utility of VFA in detecting vertebral fractures (VFs) in patients over 50  years of age, who suffered from a recent low-trauma non-severe peripheral fracture.MethodsThis was an observational, single-center, cross-sectional study conducted in patients over 50 &...
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
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