Soluplus ® based solid dispersion as fast disintegrating tablets: A combined experimental approach for enhancing the dissolution and antiulcer efficacy of famotidine.

Soluplus® based solid dispersion as fast disintegrating tablets: A combined experimental approach for enhancing the dissolution and antiulcer efficacy of famotidine. Drug Dev Ind Pharm. 2020 Jan 15;:1-29 Authors: Basha M, Salama A, Noshi SH Abstract Famotidine (FM) is considered among the first-line therapy for treatment of gastric ulcers; however, its poor aqueous solubility resulted in low bioavailability and limited therapeutic efficacy. Therefore, fast disintegrating tablet (FDT) incorporating FM solid dispersion was developed in a combined formulation approach for efficient treatment of ulcers. Within the investigated polymers, solid dispersions were prepared using the novel copolymer, Soluplus® (SP) by kneading and freeze drying techniques at various FM: SP ratios. FM solid dispersion prepared at 1:10 ratio using freeze drying (FM-SP10) manifested the highest saturation solubility, having smooth porous surface with the complete conversion of FM to the amorphous form. FDTs of FM-SP10 was produced by direct compression using three ready-to-use excipients; F-melt, Pearlitol Flash and Fujicalin. All tablets showed adequate thickness, diameter, weight variation, drug content and friability (<1%). Fujicalin-FDTs (FM-FDT-FU) exhibited the shortest disintegration time with almost complete dissolution of the drug (>95%) within 30 min. FM-FDT-FU revealed remarkable antiulcerogenic effect on ethanol induced gastric ulcers in ter...
Source: Drug Development and Industrial Pharmacy - Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research