Intratympanic Administration of N-acetylcysteine for Protection of Cisplatin-induced Ototoxicity

Conditions:   Ototoxic Hearing Loss;   Ototoxic Hearing Loss, Bilateral;   Ototoxicity;   Tinnitus Intervention:   Drug: N-acetyl cysteine Sponsor:   Centre Hospitalier Universitaire Saint Pierre Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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Authors: Monsanto RDC, Kasemodel ALP, Tomaz A, Abrahão Elias TG, Paparella MM, de Oliveira Penido N Abstract BACKGROUND: Evidence to support potential links between chronic otitis media (COM) and vestibular impairment/postural balance control issues is lacking. OBJECTIVE: To investigate whether COM associates with vestibular symptoms, balance problems, and abnormalities in vestibular function tests. METHODS: We selected patients with COM and excluded patients with any identifiable underlying causes for vestibular dysfunction. Fifty-two healthy volunteers were included as controls. All subjects underw...
Source: Journal of Vestibular Research: Equilibrium and Orientation - Category: Neuroscience Tags: J Vestib Res Source Type: research
Conditions:   Hearing Loss, Sensorineural;   Tinnitus, Subjective;   Cancer;   Chemotherapeutic Toxicity Intervention:   Diagnostic Test: High frequency pure tone audiometry Sponsors:   University of Nottingham;   National Institute for Health Research, United Kingdom;   International Stem Cell Forum Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Crincoli V, Piancino MG, Iannone F, Errede M, Di Comite M Abstract Aims: Systemic Lupus Erythematosus (SLE) is a connective tissue disease characterized by a wide range of pleomorphic pictures, including mucocutaneous, renal, musculoskeletal and neurological symptoms. It involves oral tissues, with hyposalivation, tooth decay, gingivitis, angular cheilitis, ulcers and glossitis. Temporomandibular disorders represent a heterogeneous group of inflammatory or degenerative diseases of the stomatognatic system, with algic and/or dysfunctional clinical features involving temporomandibular joint (TMJ) and related...
Source: International Journal of Medical Sciences - Category: Biomedical Science Tags: Int J Med Sci Source Type: research
Conclusion: The endoscope offers an additional viable approach to the otic capsule for the removal of intracochlear schwannoma and good audiologic outcomes can be achieved with simultaneous cochlear implantation even after partial cochlectomy.
Source: Otology and Neurotology - Category: ENT & OMF Tags: COCHLEAR IMPLANTS Source Type: research
Conclusions: Rhythmic APT wave patterns are common and may be associated with numerous temporal bone pathologies that may present with objective tinnitus. APT is a simple, rapid, and widely available tool that warrants further study to determine its value in screening of these otologic conditions.
Source: Otology and Neurotology - Category: ENT & OMF Tags: MEDICAL NEUROTOLOGY Source Type: research
Conclusions and significance: The results of this study confirmed that the cochlear nucleus of the brainstem and above part of the brainstem may play an important role in the maintenance of tinnitus. PMID: 32049565 [PubMed - as supplied by publisher]
Source: Acta Oto-Laryngologica - Category: ENT & OMF Authors: Tags: Acta Otolaryngol Source Type: research
Conclusions and significance: Two cases showed worse THI in both mixed hearing loss cases with a small hearing improvement. The mechanism of improvement is similar to tinnitus retraining therapy including hearing aid because the increase in external sound input through hearing restoration after surgery to avoid silence. PMID: 32049560 [PubMed - as supplied by publisher]
Source: Acta Oto-Laryngologica - Category: ENT & OMF Authors: Tags: Acta Otolaryngol Source Type: research
Made in Chelsea star Jamie Laing, 31, was diagnosed with tinnitus. Tinnitus is a symptom, not a condition and there is always an underlying cause, an ENT consultant surgeon explains.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Authors: Lee HY PMID: 32036637 [PubMed]
Source: Clinical and Experimental Otorhinolaryngology - Category: ENT & OMF Tags: Clin Exp Otorhinolaryngol Source Type: research
Conditions:   Tinnitus;   Depression Intervention:   Device: transcranial direct current stimulation (tDCS) and transcranial magnetic stimulation (TMS) Sponsor:   Seoul National University Hospital Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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